1204333-58-3

Basic information

• Product Name: 2,6-Difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
• Synonyms: 2,6-Difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine;2,6-Difluoropyridine-4-boronic acid pinacol ester
• CAS NO: 1204333-58-3
• Molecular Formula: C₁₁H₁₄BF₂NO₂
• Molecular Weight: 241.0421664
• Product Categories: Organic boronic acid
• Mol File: 1204333-58-3.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 363.89 °C at 760 mmHg
• Flash Point: 173.875 °C
• Appearance: Light yellow liquid
• Density: 1.205 g/cm³
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• PKA: -6.91±0.10(Predicted)
• CAS DataBase Reference: 2,6-Difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-Difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine(1204333-58-3)
• EPA Substance Registry System: 2,6-Difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine(1204333-58-3)

Safety Data

• Hazardous Substances Data: 1204333-58-3(Hazardous Substances Data)

Usage

Uses

2,6-Difluoropyridine-4-boronic acid, pinacol ester

Upstream product

• 1513-65-1 2,6-difluoro pyridine 
• 73183-34-3 bis(pinacol)diborane 

Downstream Products

• 903513-58-6 4‐bromo‐2,6‐difluoropyridine 

Relevant articles and documents

PROCESS FOR PREPARING 1-[(3R,4S)-4-CYANOTETRAHYDROPYRAN-3-YL]-3-[(2-FLUORO-6-METHOXY-4-PYRIDYL)AMINO]P YRAZOLE-4-CARBOXAMIDE

The application relates to processes for the preparation of 1-[(3R,4S) -4-cyanotetrahydropyran-3-yl]-3-[(2-fluoro-6-methoxy-4-pyridyl) amino]pyrazole-4-carboxamide (I) which include (i) a synthesis for bromo and iodo pyridine intermediates, (ii) a synthesis of a pyrazole ester intermediate which can be obtained in enantiopure form and (iii) the combination of these intermediates into compound (I).

Identification of Potent and Selective RIPK2 Inhibitors for the Treatment of Inflammatory Diseases

NOD2 (nucleotide-binding oligomerization domain-containing protein 2) is an internal pattern recognition receptor that recognizes bacterial peptidoglycan and stimulates host immune responses. Dysfunction of NOD2 pathway has been associated with a number of autoinflammatory disorders. To date, direct inhibitors of NOD2 have not been described due to technical challenges of targeting the oligomeric protein complex. Receptor interacting protein kinase 2 (RIPK2) is an intracellular serine/threonine/tyrosine kinase, a key signaling partner, and an obligate kinase for NOD2. As such, RIPK2 represents an attractive target to probe the pathological roles of NOD2 pathway. To search for selective RIPK2 inhibitors, we employed virtual library screening (VLS) and structure based design that eventually led to a potent and selective RIPK2 inhibitor 8 with excellent oral bioavailability, which was used to evaluate the effects of inhibition of RIPK2 in various in vitro assays and ex vivo and in vivo pharmacodynamic models.

SERINE/THREONINE KINASE INHIBITORS

Compounds having the formula I wherein R1, X1, X2, X3 and X4 as defined herein are inhibitors of ERK kinase. Also disclosed are compositions and methods for treating hyperproliferative disorders.