1204351-89-2

Upstream product

• 1680-44-0 4-phenyl-1H-1,2,3-triazole 
• 1680-44-0 5-phenyl-1H-1,2,3-triazole 
• 6286-30-2 2,3-Dibrom-3-phenyl-propionsaeure 

Downstream Products

• 1594929-85-7 2-(1-benzyl-1H-pyrrol-2-yl)-4-chloro-5-phenyl-2H-1,2,3-triazole 
• 1594929-36-8 1-benzyl-2-(4-chloro-5-phenyl-2H-1,2,3-triazol-2-yl)-1H-indole 

Relevant academic research and scientific papers

Facile and direct halogenation of 1,2,3-triazoles promoted by a KX-oxone system under transition metal free conditions

A convenient and efficient oxidative halogenation of 4-aryl 1,2,3-triazoles is realized at ambient temperature under transition metal free conditions. In this methodology, halogenation is achieved by using readily available potassium halides (KBr, KCl, and KI) with oxone as an oxidant under mild reaction conditions and halogenated products are obtained in good to excellent yields. In addition, the synthesized halogenated triazoles are applied for the synthesis of functionalized molecules.

Structure-activity relationship and enzyme kinetic studies on 4-aryl-1H-1,2,3-triazoles as indoleamine 2,3-dioxygenase (IDO) inhibitors

Previously, we have reported the design and synthesis of 4-aryl-1H-1,2,3-triazoles as inhibitors of indoleamine 2,3-dioxygenase (IDO), a promising therapeutic target of cancer. Here, we present the structure-activity relationship and enzyme kinetic studie