1204472-64-9

Upstream product

• 16452-01-0 ortho-cresidine 
• 94-05-3 ethyl (ethoxymethylene)cyanoacetate 
• 7085-85-0 ethyl-2-cyanoacrilate 

Downstream Products

• 1259017-83-8 4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)-6-((1,3-dioxoisoindolin-2-yl)methyl)-7-methoxyquinoline-3-carbonitrile 
• 1259017-84-9 4-(3-chloro-4-fluorophenylamino)-6-((1,3-dioxoisoindolin-2-yl)methyl)-7-methoxyquinoline-3-carbonitrile 
• 1259017-85-0 4-(3-bromophenylamino)-6-((1,3-dioxoisoindolin-2-yl)methyl)-7-methoxyquinoline-3-carbonitrile 
• 1259017-64-5 C₃₁H₂₈ClFN₄O₄S₂ 
• 1259017-65-6 C₂₄H₂₂ClFN₄O₃S₂ 
• 1259017-66-7 C₂₄H₂₃BrN₄O₃S₂ 

Relevant academic research and scientific papers

Novel dithiocarbamic acid esters derived from 6-aminomethyl-4- anilinoquinazolines and 6-aminomethyl-4-anilino-3-cyanoquinolines as potent EGFR inhibitors

Two series of dithiocarbamic acid esters, 4-anilinoquinazoline-6- ylmethylcarbamodithioic acid esters and 3-cyano-4-anilinoquinolin-6- ylmethylcarbamodithioic acid esters, were designed and synthesized. The effect of the synthesized compounds on cell proliferation was evaluated by MTT assay against three human cancer cell lines: MDA-MB-468, SK-BR-3 and HCT-116. Most of the compounds are equally or more potent than the positive control lapatinib. Three compounds (14d, 14h and 14i) were identified as dual inhibitors of the EGFR and ErbB-2 kinases and two compounds (14b and 14c) were identified as multi-target kinase inhibitors, and they are very worthy of further study. Installation of the dithiocarbamic acid ester group at the 6-position of 4-anilinoquinazoline or 3-cyano-4-anilinoquinoline could improve the inhibitory activity. Different dithiocarbamic acid ester groups significantly affect the activities. Two series of dithiocarbamic acid esters were designed and synthesized. Compound 14d was found to have higher biological activity than lapatinib. Some useful structure-activity relationships were revealed. Copyright

Microwave-assisted simple synthesis of substituted 4-quinolone derivatives

A simple and efficient method was developed for the synthesis of 4-quinolone-3-carboxylic esters and 4-quinolone-3-carbonitriles under microwave (MW) activation using anilines and acrylates as materials. All reactions demonstrated the benefits of microwave reactions: convenient operation, short reaction time, and good yields.