1204472-76-3Relevant academic research and scientific papers
Preparation of N-alkyl 2-pyridones via a lithium iodide promoted oto N-alkyl migration: Scope and mechanism
Tasker, Sarah Z.,Bosscher, Michael A.,Shandro, Christina A.,Ryu, Keun Ah,Snapper, Gregory S.,Utter, Jarrad M.,Anderson, Carolyn E.,Lanni, Erica L.,Ellsworth, Bruce A.
, p. 8220 - 8230,11 (2020/10/15)
An efficient and inexpensive LiI-promoted O- to N-alkyl migration of 2-benzyloxy-, 2-allyloxy-, and 2-propargyloxypyridines and heterocycles is reported. The reaction produces the corresponding N-alkyl 2-pyridones and analogues under green, solvent-free conditions in good to excellent yields (30 examples, 20-97% yield). This method has been shown to be intermolecular and requires heat and lithium cation to occur.
Enantioselective palladium(II)-catalyzed formal [3,3]-sigmatropic rearrangement of 2-allyloxypyridines and related heterocycles
Rodrigues, Alessandro,Lee, Ernest E.,Batey, Robert A.
supporting information; experimental part, p. 260 - 263 (2010/03/24)
(Figure Presented) Enantioselective palladium(II)-catalyzed formal [3,3]-sigmatropic rearrangement of (E)- and (Z)-allyloxy substituted N-heterocycles generates W-allyl N-heterocyclic amides In good yields and high enantioselectivities (up to 96% ee). The chiral palladacycle COP-Cl (5 mol %) Is used as a catalyst with silver(l) trifluoroacetate (10 mol %) at 35-45 °C. Examples of heterocycles synthesized include 2-pyridones, quinolin-2(1H)ones, and isoquinolin-1(2H)-ones.
