1204476-25-4

Upstream product

• 98-59-9 p-toluenesulfonyl chloride 
• 95393-67-2 2-chloro-5-hydroxy-7-methoxy-1,4-naphthoquinone 
• 1204476-24-3 toluene-4-sulfonic acid 6-chloro-3-methoxy-5,8-dioxo-5,8-dihydronaphthalen-1-yl ester 
• 77-78-1 dimethyl sulfate 

Relevant academic research and scientific papers

Synthesis and biological activities of topopyrones

Structure-activity studies were employed to investigate the stabilization of DNA-topoisomerases I and II covalent binary complexes by topopyrone analogues. The synthesis of five new topopyrone derivatives and study of their ability to stabilize DNA-topoisomerase I and DNA-topoisomerase II covalent binary complexes are described. The biochemical assays suggest that the orientation of the fused 1,4-pyrone ring and halogen substituents contribute importantly to the overall potency of the topopyrones as topoisomerase poisons.