1204524-90-2Relevant academic research and scientific papers
Oriented synthesis and in vitro anticancer activity of biquinazoline-2,2'- diones
Dou, Guolan,Shi, Daqing,Li, Yonghai
experimental part, p. 195 - 199 (2010/11/02)
The synthesis of a series of biquinazoline-2,2'-diones starting from o-nitrobenzaldehydes, anilines, and triphosgene is presented. This general approach features a novel and easy way for access to the target products. The mechanistic course of the reaction suggests the involvement of reduction, coupling, and cyclization by one-pot. These compounds were also investigated in vitro for anticancer activity, and some were found to have good anticancer activity.
