1204601-19-3Relevant academic research and scientific papers
Structure-activity relationships of N-substituted ligands for the α7 nicotinic acetylcholine receptor
Mortell, Kathleen H.,Schrimpf, Michael R.,Bunnelle, William H.,Anderson, David J.,Gronlien, Jens Halvard,Hagene, Kirsten Thorin,Gopalakrishnan, Murali
, p. 104 - 107 (2010)
A series of α7 neuronal nicotinic acetylcholine receptor ligands were designed based on a structural combination of a potent, but non-selective ligand, epibatidine, with a selective lead structure, 2. Three series of compounds in which aryl moieties were attached via a linker to different positions on the core structure were studied. A potent and functionally efficacious analog, (3aR,6aS)-2-(6-phenylpyridazin-3-yl)-5-(pyridin-3-ylmethyl)octahydropyrrolo[3,4-c]pyrrole (3a), was identified.
