1204648-94-1Relevant articles and documents
Synthesis of hydroxylated tryptanthrins as possible metabolites and characterization
Kim, Dong Hyeon,Karim, Moinul,Lu, Yang,Jahng, Yurngdong
, p. 67 - 71 (2015)
A series of dihydroxytryptanthrins was prepared by the reaction of a suitably substituted isatoic anhydride and isatin as possible metabolites of tryptanthrin. A high-performance liquid chromatography analysis of the synthetic compounds confirmed that 8,9-dihydroxytryptanthrin is the metabolite isolated from rat liver cytosolic metabolites. Although tryptanthrin shows strong cytotoxicity against human cancer cell lines, none of the hydroxylated tryptanthrins exhibit any significant cytotoxicity against selected human cancer cell lines up to 50 μm.