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CAS

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1204659-04-0

(S)-1-(4-(2-benzhydrylpyrrolidin-1-yl)-4-oxobutyl)pyrimidine-2,4(1H,3H)-dione is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 1204659-04-0 Structure

  • Basic information

    1. Product Name: (S)-1-(4-(2-benzhydrylpyrrolidin-1-yl)-4-oxobutyl)pyrimidine-2,4(1H,3H)-dione
    2. Synonyms: (S)-1-(4-(2-benzhydrylpyrrolidin-1-yl)-4-oxobutyl)pyrimidine-2,4(1H,3H)-dione
    3. CAS NO:1204659-04-0
    4. Molecular Formula:
    5. Molecular Weight: 417.508
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1204659-04-0.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: (S)-1-(4-(2-benzhydrylpyrrolidin-1-yl)-4-oxobutyl)pyrimidine-2,4(1H,3H)-dione(CAS DataBase Reference)
    10. NIST Chemistry Reference: (S)-1-(4-(2-benzhydrylpyrrolidin-1-yl)-4-oxobutyl)pyrimidine-2,4(1H,3H)-dione(1204659-04-0)
    11. EPA Substance Registry System: (S)-1-(4-(2-benzhydrylpyrrolidin-1-yl)-4-oxobutyl)pyrimidine-2,4(1H,3H)-dione(1204659-04-0)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1204659-04-0(Hazardous Substances Data)

1204659-04-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1204659-04-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,0,4,6,5 and 9 respectively; the second part has 2 digits, 0 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1204659-04:
(9*1)+(8*2)+(7*0)+(6*4)+(5*6)+(4*5)+(3*9)+(2*0)+(1*4)=130
130 % 10 = 0
So 1204659-04-0 is a valid CAS Registry Number.

1204659-04-0Downstream Products

1204659-04-0Relevant articles and documents

Synthesis and discovery of N -carbonylpyrrolidine- or N -sulfonylpyrrolidine-containing uracil derivatives as potent human deoxyuridine triphosphatase inhibitors

Miyakoshi, Hitoshi,Miyahara, Seiji,Yokogawa, Tatsushi,Chong, Khoon Tee,Taguchi, Junko,Endoh, Kanji,Yano, Wakako,Wakasa, Takeshi,Ueno, Hiroyuki,Takao, Yayoi,Nomura, Makoto,Shuto, Satoshi,Nagasawa, Hideko,Fukuoka, Masayoshi

supporting information; experimental part, p. 2960 - 2969 (2012/06/01)

Recently, deoxyuridine triphosphatase (dUTPase) has emerged as a potential target for drug development as part of a new strategy of 5-fluorouracil-based combination chemotherapy. We have initiated a program to develop potent drug-like dUTPase inhibitors based on structure-activity relationship (SAR) studies of uracil derivatives. N-Carbonylpyrrolidine- and N-sulfonylpyrrolidine- containing uracils were found to be promising scaffolds that led us to human dUTPase inhibitors (12k) having excellent potencies (IC50 = 0.15 μM). The X-ray structure of a complex of 16a and human dUTPase revealed a unique binding mode wherein its uracil ring and phenyl ring occupy a uracil recognition region and a hydrophobic region, respectively, and are stacked on each other. Compounds 12a and 16a markedly enhanced the growth inhibition activity of 5-fluoro-2′-deoxyuridine against HeLa S3 cells in vitro (EC50 = 0.27-0.30 μM), suggesting that our novel dUTPase inhibitors could contribute to the development of chemotherapeutic strategies when used in combination with TS inhibitors.

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