1204809-96-0

Basic information

• Product Name: 2-(6-Phenylpyridin-3-yl)acetonitrile
• Synonyms: 2-(6-Phenylpyridin-3-yl)acetonitrile;(6-Phenyl-pyridin-3-yl)-acetonitrile
• CAS NO: 1204809-96-0
• Molecular Formula: C₁₃H₁₀N₂
• Molecular Weight: 194.2319
• Mol File: 1204809-96-0.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(6-Phenylpyridin-3-yl)acetonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(6-Phenylpyridin-3-yl)acetonitrile(1204809-96-0)
• EPA Substance Registry System: 2-(6-Phenylpyridin-3-yl)acetonitrile(1204809-96-0)

Safety Data

• Hazardous Substances Data: 1204809-96-0(Hazardous Substances Data)

Usage

Description

2-(6-Phenylpyridin-3-yl)acetonitrile, also known as SGI-1027, is a chemical compound with the molecular formula C16H11N. It is a potent and selective inhibitor of the histone methyltransferase enzyme G9a, which is involved in gene regulation and implicated in various diseases, including cancer and neurological disorders.

Uses

Used in Pharmaceutical Industry:
2-(6-Phenylpyridin-3-yl)acetonitrile is used as a therapeutic agent for cancer treatment. It has shown promising results in preclinical studies by inhibiting the histone methyltransferase enzyme G9a, which plays a role in gene regulation and is implicated in cancer development.
Used in Research Applications:
2-(6-Phenylpyridin-3-yl)acetonitrile is used as a tool compound for studying the molecular mechanisms of histone methylation. Its ability to selectively inhibit the G9a enzyme makes it a valuable research tool for understanding the role of histone methylation in gene regulation and its implications in various diseases.
Used in Epigenetic Regulation:
2-(6-Phenylpyridin-3-yl)acetonitrile is being investigated for its potential role in epigenetic regulation. Its ability to inhibit the G9a enzyme suggests that it may have applications in modulating gene expression and treating diseases related to epigenetic dysregulation.

Upstream product

• 39891-09-3 (6-chloro-pyridin-3-yl)-acetonitrile 
• 98-80-6 phenylboronic acid 

Downstream Products

• 1372399-13-7 3-(dimethylamino)-2-(6-phenylpyridin-3-yl)acrylonitrile 
• 1372399-14-8 4-(6-phenylpyridin-3-yl)-1H-pyrazol-5-amine 
• 1372401-72-3 tert-butyl 9-amino-3-(6-phenylpyridin-3-yl)-5,6-dihydropyrazolo[1,5-a]pyrido[4,3-d]pyrimidine-7(8H)-carboxylate 
• 1372401-65-4 3-(6-phenylpyridin-3-yl)-5,6,7,8-tetrahydropyrazolo[1,5-a]pyrido[4,3-d]pyrimidin-9-amine 
• 1372401-43-8 (R)-1-(8-amino-3-(6-phenylpyridin-3-yl)-5H-pyrazolo[1,5-a]pyrrolo[3,4-d]pyrimidin-6(7H)-yl)-2-hydroxypropan-1-one 
• 1372399-15-9 tert-butyl 8-amino-3-(6-phenylpyridin-3-yl)-5H-pyrazolo[1,5-a]pyrrolo[3,4-d]pyrimidine-6(7H)-carboxylate 
• 1372399-16-0 3-(6-phenylpyridin-3-yl)-6,7-dihydro-5H-pyrazolo[1,5-a]pyrrolo[3,4-d]pyrimidin-8-amine 
• 1372398-95-2 (R)-1-(8-amino-3-(6-phenylpyridin-3-yl)-5H-pyrazolo[1,5-a]pyrrolo[3,4-d]pyrimidin-6(7H)-yl)-2-hydroxypropan-1-one 
• 1372399-17-1 3-(6-phenylpyridin-3-yl)-5,7-dihydropyrazolo[1,5-a]thieno[3,4-d]pyrimidin-8-amine 
• 1372398-96-3 3-(6-phenylpyridin-3-yl)-5,7-dihydropyrazolo[1,5-a]-6,6-dioxidothieno[3,4-d]pyrimidin-8-amine 
• 1372399-26-2 3-(6-phenylpyridin-3-yl)-6,7-dihydrospiro[cyclopenta[d]pyrazolo[1,5-a]pyrimidine-5,2'-[1,3]dithiolan]-8-amine 
• 1372399-20-6 8-amino-3-(6-phenylpyridin-3-yl)-6,7-dihydro-5H-cyclopenta[d]pyrazolo[1,5-a]pyrimidin-5-one 
• 1372398-97-4 3-(6-phenylpyridin-3-yl)-N₅-(tetrahydro-2H-pyran-4-yl)-6,7-dihydro-5H-cyclopenta[d]pyrazolo[1,5-a]pyrimidine-5,8-diamine 

Relevant articles and documents

FUSED TRICYCLIC INHIBITORS OF MAMMALIAN TARGET OF RAPAMYCIN

This invention relates to novel fused tricyclic compounds that are inhibitors of mammalian Target of Rapamycin (mTOR) kinase which is also known as FRAP, RAFT, RAPT or SEP, and are useful in the treatment of cellular proliferative diseases for example can