120491-75-0Relevant academic research and scientific papers
The regioselective iodination of quinolines, quinolones, pyridones, pyridines and uracil
Dutta, Uttam,Deb, Arghya,Lupton, David W.,Maiti, Debabrata
, p. 17744 - 17747 (2015)
A radical based direct C-H iodination protocol for quinolines, quinolones, pyridones, pyridines, and uracil has been developed. The iodination occurs in a C3 selective manner for quinolines and quinolones. Pyridones and pyridines undergo C3 and C5 iodination, while dimethyl uracil undergoes C5 iodination. Scope of the method was demonstrated through the rapid synthesis of both electron rich as well as electron poor heteroaromatic iodides. The protocol was found to be scalable and general, while a mechanism has been proposed.
HALOGENATION AND NITRATION OF 2-PYRIDONES
Faidallah, Hassan M.
, p. 281 - 288 (2007/10/02)
Halogenation of the 2-pyridones 2 afforded the corresponding mono-di- or tri-halo derivative depending on the conditions of the reaction.Nitration of 2a gave the dinitro-2-pyridone 4k, while nitration of 2c yielded the 3-nitro derivative 4p.Structures were confirmed by spectral data.
