1204975-47-2Relevant academic research and scientific papers
Chiral 2-endo-substituted 9-oxabispidines: Novel ligands for enantioselective copper(ii)-catalyzed henry reactions
Breuning, Matthias,Hein, David,Steiner, Melanie,Gessner, Viktoria H.,Strohmann, Carsten
, p. 12764 - 12769 (2009)
A flexible approach, applicable on a gram scale, to chiral 2-endosubstituted 9-oxabispidines was developed. The key intermediate, a cis-configured 6-aminomethylmorpholine-2carbonitrile, was prepared from (R)-3aminopropane-1,2-diol and 2-chloroacrylonitril
