120503-31-3

Usage

Uses

Used in Pharmaceutical Applications:
(2S,5R)-5-[6-(cyclopropylamino)-9H-purin-9-yl]tetrahydrofuran-2-ylmethanol is used as a compound with potential pharmaceutical applications due to its unique molecular structure and functional groups. (2S,5R)-5-[6-(cyclopropylamino)-9H-purin-9-yl]tetrahydrofuran-2-ylmethanol's interaction with biological systems may lead to the development of new drugs or therapies.
Used in Chemical Research:
In the field of chemical research, (2S,5R)-5-[6-(cyclopropylamino)-9H-purin-9-yl]tetrahydrofuran-2-ylmethanol is used as a compound for studying its interactions with biological systems. This research could provide insights into its potential applications in drug development and other areas of chemical and biological science.
Used in Drug Development:
(2S,5R)-5-[6-(cyclopropylamino)-9H-purin-9-yl]tetrahydrofuran-2-ylmethanol is used as a starting material or a structural component in the development of new drugs. Its unique combination of a purine base, a tetrahydrofuran ring, and a cyclopropylamino group may contribute to the creation of novel therapeutic agents.
Used in Biochemical Studies:
In the field of biochemistry, (2S,5R)-5-[6-(cyclopropylamino)-9H-purin-9-yl]tetrahydrofuran-2-ylmethanol is used as a compound for investigating its interactions with biomolecules and cellular processes. Understanding these interactions could reveal new insights into the compound's potential applications in medicine and biotechnology.
Used in Drug Delivery Systems:
(2S,5R)-5-[6-(cyclopropylamino)-9H-purin-9-yl]tetrahydrofuran-2-ylmethanol may be used as a component in the development of drug delivery systems. Its unique structure could be exploited to improve the targeting, release, or bioavailability of therapeutic agents in the body.
Used in Chemical Synthesis:
In the chemical synthesis industry, (2S,5R)-5-[6-(cyclopropylamino)-9H-purin-9-yl]tetrahydrofuran-2-ylmethanol is used as a building block or intermediate in the synthesis of more complex molecules with potential applications in various fields, including pharmaceuticals, materials science, and agrochemicals.

Upstream product

• 75788-35-1 9-Trimethylsilyl-2,6-dichlorpurin 
• 5451-40-1 2,6 dichloropurine 
• 500342-57-4 2,6-dichloro-9-(2,3-dideoxy-β-D-glyceropentofuranosyl)-9H-purine 
• 500342-63-2 2-chloro-6-cyclopropylamino-9-(2,3-dideoxy-β-D-glycero-pentofuranosyl)-9H-purine 

Relevant academic research and scientific papers

Deaza- and deoxyadenosine derivatives: Synthesis and inhibition of animal viruses as human infection models

N6-Cycloalkyl-2′,3′-dideoxyadenosine derivatives and (2-chloro)-N6-cycloheptyl-3-deazaadenosine have been synthesized and tested, along with other (deaza)purine (deoxy)nucleosides from our chemical library, as inhibitors of virus replication against Bovine Herpes Virus 1 (BHV-1) and sheep Maedi/Visna Virus (MVV). Most compounds demonstrated good antireplicative activity against MVV, showing also low cell toxicity.

Adenine and deazaadenine nucleoside and deoxynucleoside analogues: inhibition of viral replication of sheep MVV (in vitro model for HIV) and bovine BHV-1.

A series of N(6)-cycloalkyl-2',3'-dideoxyadenosine derivatives has been prepared by coupling of 2,6-dichloropurine to protected 2,3-dideoxyribose, followed by reaction with appropriate cycloalkylamines. Synthesized compounds, along with other purine nucleoside analogues previously synthesized in our laboratory, have been tested for their antiviral activity against Bovine herpesvirus 1 (BHV-1) and sheep Maedi/Visna Virus (MVV), the latter being an in vitro and in vivo model of Human Immunodeficiency Virus (HIV). All compounds showed good antireplicative activity against MVV, with the N(6)-cycloheptyl-2',3'-dideoxyadenosine (5b) being the most active [effective concentration (EC(50)) causing 50% reduction of cytopatic effects (CPE)=27 nM]. All compounds showed also a from low to very low cell toxicity, resulting in a cytotoxic dose 50 (CD(50))/EC(50) ratio in some cases higher than 1000.