120511-92-4Relevant articles and documents
A PROCESS FOR PREPARING TRISUBSTITUTED PHENYL DERIVATIVES COMPRISING A (1H-1,2,4-TRIAZOL-1-YL)ALKYL GROUP
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Page/Page column 23-24, (2011/08/03)
The present invention relates in general to the field of organic chemistry, and in particular to the preparation of phenyl derivatives comprising a (1H-1,2,4-triazol-1-yl)alkyl group such as anastrozole (2,2'-(5-((1H-1,2,4-triazol-1-yl)methyl)-1,3-phenylene) bis(2-methyl-propanenitrile).
PURIFICATION PROCESS TO PREPARE HIGHLY PURE ANASTROZOLE
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Page/Page column 9-10; 10; 11; 12; 13; 13-14, (2009/03/07)
The present invention relates to an industrially advantageous method for the purification of anastrozole of Formula (I), wherein isoanastrozole of Formula (VI), present in crude anastrozole as an impurity, is removed by using gel purification.
Novel processes for preparing substantially pure anastrozole
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Page/Page column 10, (2008/06/13)
The present invention provides novel processes for purifying anastrozole, devoid of using liquid chromatography. The purification processes are via the isolated anastrozole salt forms, either by crystallization or by selective acidic extractions, and optionally in both cases, converting the purified anastrozole salt to anastrozole base. Also provided is an improved process for the synthesis of anastrozole, which is obtained by alkylating the isolated and purified starting material 3,5-bis(2-cyanoprop-2-yl)benzylbromide, the process being devoid of using toxic, hazardous and environmental unfriendly solvents and reagents.