1205545-76-1Relevant academic research and scientific papers
Unexpected lactonization accompanying addition of ethyl acetoacetate to chalcones derived from 3-acetylthiophene
Budak, Yakup,Findik, Esra
experimental part, p. 1255 - 1261 (2012/01/03)
Chalcone derivatives containing thiophene ring were prepared by the condensation of 3-acetylthiophene with aromatic aldehydes in excellent yields. The addition of ethyl acetoacetate to chalcone derivatives 3a-3h in the presence of solid NaOH in CH2Cl2 resulted in the formation of the mixture of bicyclic lactone derivatives 5a-5h and 6-(ethoxycarbonyl) cyclohexenone derivatives 6a-6h.
