120564-72-9

Basic information

• Product Name: 7-Amino-2-pyridin-4-yl[1,2,4]triazolo-[1,5-a]pyrimidine-6-carbonitrile
• Synonyms: 7-Amino-2-pyridin-4-yl[1,2,4]triazolo-[1,5-a]pyrimidine-6-carbonitrile
• CAS NO: 120564-72-9
• Molecular Formula: C11H7N7
• Molecular Weight: 237.22018
• Mol File: 120564-72-9.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 7-Amino-2-pyridin-4-yl[1,2,4]triazolo-[1,5-a]pyrimidine-6-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 7-Amino-2-pyridin-4-yl[1,2,4]triazolo-[1,5-a]pyrimidine-6-carbonitrile(120564-72-9)
• EPA Substance Registry System: 7-Amino-2-pyridin-4-yl[1,2,4]triazolo-[1,5-a]pyrimidine-6-carbonitrile(120564-72-9)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 120564-72-9(Hazardous Substances Data)

Upstream product

• 3652-17-3 3-amino-5-(4-pyridyl)-1,2,4-triazole 
• 123-06-8 Ethoxymethylenemalononitrile 

Relevant articles and documents

Chemotherapeutic Agents : Part X - Synthesis of 2-Pyridyltriazolopyrimidines as Leishmanicides

2-Pyridyl-7-hydroxy-5-methyl-triazolopyrimidines (2a,b) have been prepared by condensation of 1a,b with ethyl acetoacetate in acetic acid and transformed into 2-pyridyl-7-chloro-5-methyl-triazolopyrimidines (3) with phosphoryl chloride.Nucleophilic displacement of the chloro group in 3 by amines and hydrazine provides 4a-h and 5 respectively.Boiling of 3 with thiourea in ethanol gives 2-pyridyl-7-mercapto-5-methyl-triazolopyrimidine (6).The hydrazine 5 on reaction with ethyl acetoacetate forms the hydrazone (7).Condensation of 1a,b with acetylacetone, ethoxymethylenemalononitrile, ethyl ethoxymethylenecyanoacetate and diethyl ethoxymethylenemalonate yields 8, 9, 10 and 11 respectively.Similarly, 12a-e are prepared by condensation of 1 with β-ketoesters.Fusion of 1 with β,β-bis(methylmercapto)-α-cyanoacrylonitrile and methyl β,β-bis(methylmercapto)-α-cyanoacrylate at 170-180 deg C provides 15 and 16 respectively.