120566-68-9

Upstream product

• 108-24-7 acetic anhydride 
• 120566-66-7 -4-<<2-Hydroxy-1-phenylethyl>amino>-4-oxo-2-butenoic acid 

Downstream Products

• 120566-70-3 5-<(S)-2-(Acetyloxy)-1-phenylethyl>-3a,6a-dihydro-1-methylpyrrolo<3,4-d>-1,2,3-triazole-4,6(1H,5H)-dione 
• 120566-72-5 Acetic acid 2-(6-methyl-2,4-dioxo-3,6-diaza-bicyclo[3.1.0]hex-3-yl)-2-phenyl-ethyl ester 
• 127381-64-0 <3aR<1<1S^*,3(R^*),5R^*,6R^*>,3aα,6α,7aβ>>-1-<<3-<2-(Acetyloxy)-1-phenylethyl>-8-methyl-2,4-dioxo-3,8-diazabicyclo<3.2.1>oct-6-yl>carbonyl>hexahydro-8,8-dimethyl-3H-3a,6-methano-2,1-benzisothiazole 2,2-dioxide 
• 120566-77-0 <1R,S<1α,3(S^*,R^*),5α,6α>>-3-<2-(Acetyloxy)-1-phenylethyl>-8-methyl-2,4-dioxo-3,8-diazabicyclo<3.2.1>octane-6-carboxylic acid methyl ester 
• 120566-72-5 (S)-3-<2-(Acetyloxy)-1-phenylethyl>-6-methyl-3,6-diazabicyclo<3.1.0>hexane-2,4-dione 

Relevant academic research and scientific papers

Method for preparing homochiral maleimide intermediates, via silylation techniques

A method is provided for preparing homochiral maleimide intermediates of the structure STR1 wherein R7, R8 and R9 are as defined herein by reacting a homochiral amine of the structure STR2 with maleic anhydride and a silylating agent. The maleimide intermediate is used in the enantio-selective preparation of thromboxane A2 receptor antagonists.

7-oxabicycloheptane carboxylic acid prostaglandin analog intermediates useful in the preparation of anti-thrombotic and anti-vasospastic compounds and method for preparing same

A method is provided for preparing carboxylic acid intermediates of the structure STR1 wherein an aldehyde of the structure STR2 is prepared and subjected to a Horner-Emmons reaction to form the ester of the structure STR3 and the ester is hydrogenated to the carboxylic acid which may be used in making the final anti-thrombotic--anti-vasospastic compounds.