1205667-28-2

Basic information

• Product Name: C₅₁H₅₇NO₆SSi
• Synonyms: C₅₁H₅₇NO₆SSi
• CAS NO: 1205667-28-2
• Molecular Weight: 840.168
• Mol File: 1205667-28-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: C₅₁H₅₇NO₆SSi(CAS DataBase Reference)
• NIST Chemistry Reference: C₅₁H₅₇NO₆SSi(1205667-28-2)
• EPA Substance Registry System: C₅₁H₅₇NO₆SSi(1205667-28-2)

Safety Data

• Hazardous Substances Data: 1205667-28-2(Hazardous Substances Data)

Upstream product

• 1043577-31-6 (S,E)-2-(trimethylsilyl)ethyl 3-(((S)-2-amino-3-methylbutanoyl)oxy)-7-(tritylthio)hept-4-enoate 
• 68858-20-8 Fmoc-Val-OH 
• 1205666-87-0 C₃₈H₃₉NO₂S₃ 
• 3695-77-0 triphenylmethanethiol 
• 542-28-9 3,4,5,6-tetrahydro-2H-pyran-2-one 
• 2916-68-9 2-(Trimethylsilyl)ethanol 
• 180973-22-2 (2E)-5-[(triphenylmethyl)thio]-2-pentenal 
• 84624-17-9 N-(9-fluorenylmethoxycarbonyl)-D-valine 

Downstream Products

• 1132667-29-8 C₄₂H₄₄N₄O₄S₂ 
• 1043577-37-2 (5R,8S,11S)-8-isopropyl-5-methyl-11-((E)-4-(tritylthio)but-1-en-1-yl)-10-oxa-3,17-dithia-7,14,19,20-tetraazatricyclo[14.2.1.12,5]icosa-1⁽¹⁸⁾,2⁽²⁰⁾,16⁽¹⁹⁾-triene-6,9,13-trione 
• 1009815-87-5 largazole 
• 1132667-28-7 (S,E)-2-(trimethylsilyl)ethyl 3-(((S)-2-((R)-2-(6-(((tert-butoxycarbonyl)amino)methyl)pyridin-2-yl)-4-methyl-4,5-dihydrothiazole-4-carboxamido)-3-methylbutanoyl)oxy)-7-(tritylthio)hept-4-enoate 
• 1205666-79-0 C₅₀H₆₄N₄O₉SSi 

Relevant articles and documents

METHOD FOR PREPARING LARGAZOLE ANALOGS AND USES THEREOF

Analogs of largazole are described herein. Methods of treating cancer and blood disorders using largazole and largazole analogs and pharmaceutical compositions comprising the same are additionally described herein. Methods for preparing largazole analogs are likewise described.

Synthesis and histone deacetylase inhibitory activity of largazole analogs: Alteration of the zinc-binding domain and macrocyclic scaffold

Fourteen analogs of the marine natural product largazole have been prepared and assayed against histone deacetylases (HDACs) 1, 2, 3, and 6. Olefin cross-metathesis was used to efficiently access six variants of the side-chain zinc-binding domain, while adaptation of our previously reported modular synthesis allowed probing of the macrocyclic cap group.