120570-48-1

Basic information

• Product Name: 4-THIAZOLEACETIC ACID, 2-AMINO-ALPHA-(HYDROXYIMINO)
• Synonyms: 4-THIAZOLEACETIC ACID, 2-AMINO-ALPHA-(HYDROXYIMINO);2-(2-amino-1,3-thiazolyl-4-yl)-2-hydroxyiminoacetic acid;4-THIAZOLEACETICACID,2-AMINO-A-(HYDROXYIMINO);4-Thiazoleacetic acid, 2-amino-α-(hydroxyimino)-;2-Athiaa;2-(2-AMinothiazol-4-yl)-2-(hydroxyiMino)acetic acid
• CAS NO: 120570-48-1
• Molecular Formula: C₅H₅N₃O₃S
• Molecular Weight: 187.18
• Mol File: 120570-48-1.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 539.4 °C at 760 mmHg
• Flash Point: 280 °C
• Appearance: /
• Density: 1.92 g/cm³
• Vapor Pressure: 1.82E-12mmHg at 25°C
• Refractive Index: 1.798
• PKA: 2.10±0.10(Predicted)
• CAS DataBase Reference: 4-THIAZOLEACETIC ACID, 2-AMINO-ALPHA-(HYDROXYIMINO)(CAS DataBase Reference)
• NIST Chemistry Reference: 4-THIAZOLEACETIC ACID, 2-AMINO-ALPHA-(HYDROXYIMINO)(120570-48-1)
• EPA Substance Registry System: 4-THIAZOLEACETIC ACID, 2-AMINO-ALPHA-(HYDROXYIMINO)(120570-48-1)

Safety Data

• Hazardous Substances Data: 120570-48-1(Hazardous Substances Data)

Usage

General Description

4-Thiazoleacetic acid, 2-amino-alpha-(hydroxyimino) is a chemical compound with the molecular formula C5H6N2O3S. It is a thiazole derivative with a hydroxyimino group attached to the alpha carbon and an amino group attached to the 2-position of the thiazole ring. 4-THIAZOLEACETIC ACID, 2-AMINO-ALPHA-(HYDROXYIMINO) has been studied for its potential pharmacological and biological activities, including its potential use as an antibacterial agent. It is also a key intermediate in the synthesis of various pharmaceutical and agrochemical compounds. Additionally, it has been investigated for its potential use in the treatment of various health conditions, including cancer and inflammatory diseases.

InChI:InChI=1/C5H5N3O3S/c6-5-7-2(1-12-5)3(8-11)4(9)10/h1,11H,(H2,6,7)(H,9,10)/b8-3-

Upstream product

• 60845-81-0 ethyl 2-amino-α-(hydroxyimino)-4-thiazole acetate 

Downstream Products

• 914358-45-5 syn-2-(2-aminothiazol-4-yl)-2-(methylcarbonyloxyimino)-acetic acid 

Relevant articles and documents

Preparation method of aminothiazole acetyloxime acid with controllable particle size

The invention relates to a preparation method of aminothiazole acetyloxime acid with a controllable particle size, and belongs to the technical field of chemical pharmacy. The preparation method comprises the following steps: ahydrolysis step: hydrolyzing ethyl 2-(2-aminothiazole-4-yl)-2-hydroxyiminoacetate serving as a raw material to generate a compound 1; an acylation step: dropwisely adding an acylating agent into the system to perform acylation reaction to obtain a compound 2; and a crystallization step: adding activated carbon into the reaction system for decolorization, then dropwise adding an acidic solution into the system at different temperatures to control the pH value of the system, and after the solid is separated out, carrying out centrifugal drying to obtain a compound 3 with controllable particle size. According to the method, by controlling different acid liquor adding temperatures, the particle size of the prepared aminothiazole acetyloxime acid is controllable; and the technological process is simple to operate and suitable for industrial production.