120583-62-2Relevant articles and documents
Resin glycosides from Ipomoea wolcottiana as modulators of the multidrug resistance phenotype in vitro
Corona-Casta?eda, Berenice,Rosas-Ramírez, Daniel,Casta?eda-Gómez, Jhon,Aparicio-Cuevas, Manuel Alejandro,Fragoso-Serrano, Mabel,Figueroa-González, Gabriela,Pereda-Miranda, Rogelio
, p. 48 - 57 (2016)
Recycling liquid chromatography was used for the isolation and purification of resin glycosides from the CHCl3-soluble extracts prepared using flowers of Ipomoea wolcottiana Rose var. wolcottiana. Bioassay-guided fractionation, using modulation of both antibiotic activity against multidrug-resistant strains of Gram-negative bacteria and vinblastine susceptibility in breast carcinoma cells, was used to isolate the active glycolipids as modulators of the multidrug resistance phenotype. An ester-type dimer, wolcottine I, one tetra- and three pentasaccharides, wolcottinosides I-IV, in addition to the known intrapilosin VII, were characterized by NMR spectroscopy and mass spectrometry. In vitro assays established that none of these metabolites displayed antibacterial activity (MIC > 512 μg/mL) against multidrug-resistant strains of Escherichia coli, and two nosocomial pathogens: Salmonella enterica serovar Typhi and Shigella flexneri; however, when tested (25 μg/mL) in combination with tetracycline, kanamycin or chloramphenicol, they exerted a potentiation effect of the antibiotic susceptibility up to eightfold (64 μg/mL from 512 μg/mL). It was also determined that these non-cytotoxic (CI50 > 8.68 μM) agents modulated vinblastine susceptibility at 25 μg/mL in MFC-7/Vin+ cells with a reversal factor (RFMCF-7/Vin+) of 2-130 fold.
Novel acylated lipo-oligosaccharides from the tubers of Ipomoea batatas
Yin, Yong-Qin,Wang, Jun-Song,Luo, Jian-Guang,Kong, Ling-Yi
experimental part, p. 466 - 473 (2009/05/31)
Nine new lipo-oligosaccharides, batatosides H-P, were isolated from the tubers of Ipomoea batatas (Convolvulaceae). Spectral and chemical methods allowed to characterize them as tetra- or penta-saccharides that form a macrolactone with the aglycone, (11S)