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120586-50-7

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120586-50-7 Usage

General Description

The chemical 1,2-Dithiane-4,5-diol, 1,1-dioxide, trans- is a compound with the molecular formula C4H8O4S2. It is also known as trans-4,5-Dihydroxy-1,2-dithiane 1,1-dioxide and is a white to light yellow solid in its pure form. 1,2-Dithiane-4,5-diol, 1,1-dioxide, trans- is used as a reagent in organic synthesis, particularly in the formation of cyclic sulfones and as a protecting group for aldehydes and ketones. It is known to be stable under normal temperatures and pressures, and has a very low solubility in water. The trans- form isomer of this compound has been found to be more stable than its cis- form counterpart.

Check Digit Verification of cas no

The CAS Registry Mumber 120586-50-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,0,5,8 and 6 respectively; the second part has 2 digits, 5 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 120586-50:
(8*1)+(7*2)+(6*0)+(5*5)+(4*8)+(3*6)+(2*5)+(1*0)=107
107 % 10 = 7
So 120586-50-7 is a valid CAS Registry Number.
InChI:InChI=1/C4H8O4S2/c5-3-1-9-10(7,8)2-4(3)6/h3-6H,1-2H2/t3-,4-/m0/s1

120586-50-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 1,2-Dithiane-4,5-diol, 1,1-dioxide, trans-

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:120586-50-7 SDS

120586-50-7Upstream product

120586-50-7Downstream Products

120586-50-7Relevant articles and documents

Synthesis, resolution, and determination of the absolute configuration of the enantiomers of cis-4,5-dihydroxy-1,2-dithiane 1,1-dioxide, an HIV-1 NCp7 inhibitor

Mayasundari, Anand,Rice, William G.,Diminnie, Jonathan B.,Baker, David C.

, p. 3215 - 3219 (2003)

The anti-HIV activity of (±)-cis-4,5-dihydroxy-1,2-dithiane 1,1-dioxide [(±)-cis-1,1-dioxo-[1,2]-dithiane-4,5-diol, NSC-624151] and its attack on the zinc finger domain of the HIV-1 nucleocapsid p7 (NCp7) protein has been established [Rice, W. G.; Baker, D. C.; Schaeffer, C. A.; Graham, L.; Bu, M.; Terpening, S.; Clanton, D.; Schultz, R.; Bader, J. P.; Buckheit, R. W.; Field, L.; Singh, P. K. Turpin, J. A. Antimicrob. Agents Chemother. 1997, 41, 419]. In order to determine which enantiomer of NSC-624151 is the more active component, the compound was resolved via its bis-'Mosher ester', which was prepared via its reaction with two equiv of (-)-(R)-α-methoxy-α-(trifluoromethyl)phenylacetyl chloride. The diastereoisomeric esters were separated, and each ester was hydrolyzed to yield enantiomers with [α]D21 +151° (c 0.5, MeOH) and [α]D21 -146° (c 0.5, MeOH). Single-crystal X-ray analysis of the (-)-bis-'Mosher ester' showed that the (-)-enantiomer is the (4S, 5R)-compound. The (-)-enantiomer (NSC 693195) was ca. twice as active (EC50 8.8±0.2 μM) as its (+)-counterpart (NSC 693194) (EC50 16.2±2.4 μM) in the XTT assay against HIV-1. All three compounds were found to be approximately equally effective in promoting Zn ejection from the NCp7 zinc finger. As the more anti-HIV active enantiomer is only slightly more active than the racemic form, it appears to offer no advantages over the racemic form.

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