120607-52-5Relevant articles and documents
Synthesis of Various Pyrazole-1-carbonylindoles
Hiremath, Shivayogi P.,Ullagaddi, Ashok,Sekhar, K. Raja,Purohit, Muralidhar G.
, p. 758 - 762 (2007/10/02)
Indole-2-carbohydrazides (1a-n) when heated with acetylacetone and ethyl acetoacetate in methanol afford the substituted 2-(3',5'-dimethylpyrazole-1'-carbonyl)indoles (2a-n) and 3-methyl-1(2'-indolyl)-5(4H)-pyrazolones (3e-a), respectively in good yields.The schiff's bases (4a-h) from hydrazides (1a-h) and acetophenone on reaction with POCl3 and DMF produce the substituted 2-(4'-formyl-3'-phenylpyrazole-1'-carbonyl)indoles (5a-h).Indole-3-carboxaldehydes (6a-f) undergo condensation with ethyl cyanoacetate and malononitrile to give the acrylonitriles 7a-f and 9a-e which on reaction with hydrazine hydrate yield 3-amino-5-hydroxy-4-(3'-indolylmethylene)pyrazoles (8a-f) and 3,5-diamino-4-(3'-indolylmethylene)pyrazoles (10a-e), respectively.Similarly indole-2-carboxaldehydes (11a-d) react with ethyl cyanoacetate and hydrazine hydrate to furnish the respective pyrazoles (13a-d).