120609-54-3

Upstream product

• 93287-51-5 (S)-2-[(S)-2-({(S)-1-[(S)-2-((S)-2-Benzyloxycarbonylamino-5-guanidino-pentanoylamino)-5-guanidino-pentanoyl]-pyrrolidine-2-carbonyl}-amino)-3-phenyl-propionylamino]-3-(1H-imidazol-4-yl)-propionic acid methyl ester 
• 1234-35-1 Z-Arg-OH 
• 75350-57-1 (S)-methyl 3-(1H-imidazole-4-yl)-2-((S)-3-phenyl-2-((S)-pyrrolidine-2-carboxamido)propanamido)propanoate 
• 120609-81-6 (S)-2-((S)-2-{[(S)-1-((S)-2-Amino-5-guanidino-pentanoyl)-pyrrolidine-2-carbonyl]-amino}-3-phenyl-propionylamino)-3-(1H-imidazol-4-yl)-propionic acid methyl ester 

Relevant academic research and scientific papers

Renin inhibitors. Synthesis of transition-state analogue inhibitors containing phosphorus cid derivatives at the scissile bond

The synthesis of five amino phosphorus derivatives, 1a-e, is described. The derivatives were incorporated into a series (18) of analogues of the 5-14 portion of angiotensinogen, in most cases at the scissile Leu-Val bond. The resultant compounds were test