1206126-39-7

Basic information

• Product Name: 1-((2R,3R,4R,5S)-3,4-dihydroxy-5-(iodomethyl)-3-methyltetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione
• Synonyms: 1-((2R,3R,4R,5S)-3,4-dihydroxy-5-(iodomethyl)-3-methyltetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione;KMYZFCGARHPDAV-VPCXQMTMSA-N
• CAS NO: 1206126-39-7
• Molecular Formula: C₁₀H₁₃IN₂O₅
• Molecular Weight: 368.12509
• Mol File: 1206126-39-7.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-((2R,3R,4R,5S)-3,4-dihydroxy-5-(iodomethyl)-3-methyltetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 1-((2R,3R,4R,5S)-3,4-dihydroxy-5-(iodomethyl)-3-methyltetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione(1206126-39-7)
• EPA Substance Registry System: 1-((2R,3R,4R,5S)-3,4-dihydroxy-5-(iodomethyl)-3-methyltetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione(1206126-39-7)

Safety Data

• Hazardous Substances Data: 1206126-39-7(Hazardous Substances Data)

Usage

General Description

The chemical "1-((2R,3R,4R,5S)-3,4-dihydroxy-5-(iodomethyl)-3-methyltetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione" is a compound with a pyrimidine-dione structure attached to a tetrahydrofuran ring. It contains a hydroxyl group and an iodomethyl group, as well as a methyl group in the tetrahydrofuran ring. 1-((2R,3R,4R,5S)-3,4-dihydroxy-5-(iodomethyl)-3-methyltetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione has potential applications in the pharmaceutical industry, as it may possess biological activity. Its specific properties and potential uses would need to be further investigated through research and testing.

Upstream product

• 31448-54-1 2'-C-methyluridine 

Downstream Products

• 1613589-03-9 C₂₁H₂₁FN₂O₉ 
• 1613591-96-0 isopropyl ((((2S,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-fluoro-3,4-dihydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-L-alaninate 
• 1613590-66-1 C₂₁H₂₂FN₃O₈ 
• 1613590-70-7 4'-fluoro-2'-methyluridine-5'-(O-phenyl)-N-(S)-1-(isopropoxycarbonyl)ethyl thiophosphoramidate 
• 1613590-85-4 C₂₂H₂₈ClFN₃O₁₀P 
• 1613590-86-5 C₂₄H₃₀ClFN₃O₁₁P 
• 1613590-82-1 (2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-fluoro-2-(iodomethyl)-4-methyltetrahydrofuran-3,4-diyl dibenzoate 
• 1613590-83-2 (2S,3S,4R,5R)-2-((benzoyloxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-fluoro-4-methyltetrahydrofuran-3,4-diyl dibenzoate 

Relevant articles and documents

Structure-activity relationship of uridine-based nucleoside phosphoramidate prodrugs for inhibition of dengue virus RNA-dependent RNA polymerase

To identify a potent and selective nucleoside inhibitor of dengue virus RNA-dependent RNA polymerase, a series of 2′- and/or 4′-ribose sugar modified uridine nucleoside phosphoramidate prodrugs and their corresponding triphosphates were synthesized and evaluated. Replacement of 2′-OH with 2′-F led to be a poor substrate for both dengue virus and human mitochondrial RNA polymerases. Instead of 2′-fluorination, the introduction of fluorine at the ribose 4′-position was found not to affect the inhibition of the dengue virus polymerase with a reduction in uptake by mitochondrial RNA polymerase. 2′-C-ethynyl-4′-F-uridine phosphoramidate prodrug displayed potent anti-dengue virus activity in the primary human peripheral blood mononuclear cell-based assay with no significant cytotoxicity in human hepatocellular liver carcinoma cell lines and no mitochondrial toxicity in the cell-based assay using human prostate cancer cell lines.

SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGS THEREOF

Disclosed herein are nucleosides, nucleotides and nucleotide analogs, methods of synthesizing the same and methods of treating diseases and/or conditions such as a Picornavirus and/or Flaviviridae infection with one or more nucleosides, nucleotides and nucleotide analogs.

SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGS THEREOF

Disclosed herein are nucleosides, nucleotide analogs, methods of synthesizing nucleotide analogs and methods of treating diseases and/or conditions such as a Filoviridae virus infection with one or more nucleosides and/or nucleotide analogs.