1206164-52-4Relevant academic research and scientific papers
Studies on pyrrolidinones. On the application of copper-catalyzed arylation of methyl pyroglutamate to obtain a new benzo[de]quinoline scaffold
Ghinet, Alina,Oudir, Souhila,Hénichart, Jean-Pierre,Rigo, Beno?t,Pommery, Nicole,Gautret, Philippe
, p. 215 - 221 (2010)
Optimized conditions for copper-catalyzed N-arylation of methyl pyroglutamate are described. These studies permitted the synthesis of methyl N-naphthylpyroglutamate, which was then cyclized to a ketone. The known dehydration of amidoketones by PPA was extended to this new scaffold to lead to a novel condensed benzo[de]quinoline with potential antioxidative activity.
