1206191-08-3Relevant articles and documents
Discovery and synthesis of cyclohexenyl derivatives as modulators of CC chemokine receptor 2 activity
Brown, Gregory D.,Shi, Qing,Delucca, George V.,Batt, Douglas G.,Galella, Michael A.,Cvijic, Mary-Ellen,Liu, Rui-Qin,Qiu, Feng,Zhao, Qihong,Barrish, Joel C.,Carter, Percy H.
, p. 662 - 666 (2016/01/09)
A novel cyclohexenyl series of CCR2 antagonists has been discovered. This series of small, rigid compounds exhibits submicromolar binding affinity for CCR2. Modification of the substituents on the cyclohexene ring led to the identification of potent CCR2 antagonists. Progress from initial lead 5 (IC50 = 700 nM) to (-)-38 (IC50 = 9.0 nM) is discussed.
CYCLOHEXENYL MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY
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Page/Page column 45, (2010/04/03)
The present application describes modulators of MCP-1 or CCR-2 of formula,(I) or stereoisomers or prodrugs or pharmaceutically acceptable salts thereof, wherein T, W, X, Y, Z, R1, R2, R4 and R6, are defined here
