1206191-70-9Relevant academic research and scientific papers
Enhanced selectivity profile of pyrazole-urea based DFG-out p38α inhibitors
Liu, Hu,Kuhn, Cyrille,Feru, Frederic,Jacques, Suzanne L.,Deshmukh, Gayatri D.,Ye, Ping,Rennie, Glen R.,Johnson, Theresa,Kazmirski, Steven,Low, Simon,Coli, Rocco,Ding, Yuan-Hua,Cheng, Alan C.,Tecle, Haile,English, Jessie M.,Stanton, Robert,Wu, Joe C.
experimental part, p. 4885 - 4891 (2010/10/03)
By targeting an extended region of the conventional 'DFG-out' pocket of p38α, while minimizing interactions with the specificity pocket and eliminating interactions with the adenine binding site, we are able to design and synthesize a number of pyrazole-u
