1206191-97-0Relevant academic research and scientific papers
Design, synthesis, and biological evaluation of 7H-thiazolo[3,2-b]-1,2,4- triazin-7-one derivatives as acetylcholinesterase inhibitors
Liu, Si-Jie,Yang, Liu,Liu, Xiao-Guang,Luo, Ying,Cao, Zi-Jian,Wan, David Chi Cheong,Lin, Huang-Quan,Hu, Chun
, p. 5 - 8 (2010)
The docking study on a series of 7H-thiazolo[3,2-b]-1,2,4-triazin-7-one derivatives with acetylcholinesterase has been demonstrated. The synthesis and characterization of a series of 7H-thiazolo[3,2-b]-1,2,4-triazin-7-one derivatives were described. All target compounds were evaluated in vitro for the inhibitory activities against AChE via Ellman colorimetric assay. Most of the target compounds possessed anti-acetylcholinesterase activity. The preliminary structure-activity relationships were discussed.
