120642-58-2

Upstream product

• 16800-68-3 1-acetyl-2,3-dihydro-1H-indol-3-one 
• 1122-91-4 4-bromo-benzaldehyde 

Downstream Products

• 96682-75-6 2-Amino-3-(4-bromo-phenyl)-1H-quinolin-4-one 
• 127832-30-8 2-[1-Amino-1-(4-bromo-phenyl)-meth-(E)-ylidene]-1,2-dihydro-indol-3-one 

Relevant academic research and scientific papers

N-heterocyclic carbene catalyzed formal [3+2] annulation reaction of enals: An efficient enantioselective access to spiro-heterocycles

A highly enantioselective N-heterocyclic carbene (NHC) catalyzed formal [3+2] annulation of α,β-unsaturated aldehydes with azaaurones or aurone generating spiro-heterocycles has been developed. The protocol represents a unique NHC-activation-based approach to access spiro-heterocyclic derivatives bearing a quaternary stereogenic center with high optical purity (up to 95 % ee).