1206456-44-1

Basic information

• Product Name: Olopatadine Isopropyl ester Hydrochloride
• Synonyms: Olopatadine Isopropyl ester Hydrochloride;Olopatadine Isopropyl ester
• CAS NO: 1206456-44-1
• Molecular Formula: C24H29NO3
• Molecular Weight: 379.49196
• Mol File: 1206456-44-1.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 505.8±50.0 °C(Predicted)
• Appearance: /
• Density: 1.132±0.06 g/cm3(Predicted)
• Storage Temp.: Amber Vial, -20°C Freezer
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 9.17±0.28(Predicted)
• CAS DataBase Reference: Olopatadine Isopropyl ester Hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: Olopatadine Isopropyl ester Hydrochloride(1206456-44-1)
• EPA Substance Registry System: Olopatadine Isopropyl ester Hydrochloride(1206456-44-1)

Safety Data

• Hazardous Substances Data: 1206456-44-1(Hazardous Substances Data)

Usage

Uses

Olopatadine Isopropyl Ester is an intermediate used to prepare Olopatadine (O575000, HCl salt) via Wittig reaction. Olopatadine is a dual acting histamine H1-receptor antagonist and mast cell stabilizer.

Relevant articles and documents

Process for obtaining olopatadine and intermediates

Olopatadine can be obtained by means of a process comprising hydrolysis of a compound of general formula (II), wherein Y is OR1, wherein R1 is C1-C7 alkyl, C3-C7 cycloalkyl, aryl, or heterocycle; or NR2R3, wherein R2 and R3, independently from each other, are C1-C7 alkyl, aryl, or R2 and R3 together with the nitrogen atom to which they are bound form a heterocycle of 3 to 7 members, obtained by means of a process comprising reacting the corresponding ester or amide of 6,11-dihydro-11-oxodibenz[b,e]oxepin-2-acetic acid with a suitable Witting reagent, in the presence of a base in a reaction medium comprising an organic solvent.