1206460-07-2Relevant academic research and scientific papers
4,5,6-Trisubstituted piperidinones as conformationally restricted ceramide analogues: Synthesis and evaluation as inhibitors of sphingosine and ceramide kinases and as NKT cell-stimulatory antigens
Mathew, Thresen,Cavallari, Marco,Billich, Andreas,Bornancin, Frederic,Nussbaumer, Peter,De Libero, Gennaro,Vasella, Andrea
, p. 1688 - 1715 (2009)
The conformationally based piperidinone sphingosine analogues 7, 8, 15, and 16 were synthesized from allylic alcohol 34 via lactams 31 and 32. The L-arabino diol 7 and the L-ribo diol 8 were transformed into the amino alcohols 17-24. The L-gluco ceramide
