Cas 1206524-77-7,(1R,2R)-2-(pent-4-en-1-yl)cyclopropanol

1206524-77-7

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Basic information

Product Name: (1R,2R)-2-(pent-4-en-1-yl)cyclopropanol
Synonyms: (1R,2R)-2-(pent-4-en-1-yl)cyclopropanol
CAS NO:1206524-77-7
Molecular Formula:
Molecular Weight: 126.199
EINECS: N/A
Product Categories: N/A
Mol File: 1206524-77-7.mol
Article Data: 3

Chemical Properties

Melting Point: N/A
Boiling Point: N/A
Flash Point: N/A
Appearance: N/A
Density: N/A
Refractive Index: N/A
Storage Temp.: N/A
Solubility: N/A
CAS DataBase Reference: (1R,2R)-2-(pent-4-en-1-yl)cyclopropanol(CAS DataBase Reference)
NIST Chemistry Reference: (1R,2R)-2-(pent-4-en-1-yl)cyclopropanol(1206524-77-7)
EPA Substance Registry System: (1R,2R)-2-(pent-4-en-1-yl)cyclopropanol(1206524-77-7)

Safety Data

Hazard Codes: N/A
Statements: N/A
Safety Statements: N/A
WGK Germany:
RTECS:
HazardClass: N/A
PackingGroup: N/A
Hazardous Substances Data: 1206524-77-7(Hazardous Substances Data)

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Check Digit Verification of cas no

The CAS Registry Mumber 1206524-77-7 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,0,6,5,2 and 4 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1206524-77:
(9*1)+(8*2)+(7*0)+(6*6)+(5*5)+(4*2)+(3*4)+(2*7)+(1*7)=127
127 % 10 = 7
So 1206524-77-7 is a valid CAS Registry Number.

1206524-77-7Upstream product

1206524-77-7Downstream Products

1026200-27-0 3-methyl-N-({[(1R,2R)-2-pent-4-en-1-ylcyclopropyl]oxy}carbonyl)-L-valine

1206524-77-7Relevant articles and documents

METHODS AND INTERMEDIATES FOR THE PREPARATION OF MACROLACTAMS

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Page/Page column 35; 36, (2015/07/07)

The present invention relates to synthetic processes useful in the preparation of macrolactams that inhibit hepatitis C virus (HCV), specifically macrolactam compounds that inhibit the HCV NS3 protease activity and have application in the treatment of conditions caused by HCV. The present invention also encompasses intermediates useful in the disclosed synthetic processes and the methods of their preparation.

Discovery of MK-5172, a macrocyclic hepatitis C virus NS3/4a protease inhibitor

Harper, Steven,McCauley, John A.,Rudd, Michael T.,Ferrara, Marco,DiFilippo, Marcello,Crescenzi, Benedetta,Koch, Uwe,Petrocchi, Alessia,Holloway, M. Katharine,Butcher, John W.,Romano, Joseph J.,Bush, Kimberly J.,Gilbert, Kevin F.,McIntyre, Charles J.,Nguyen, Kevin T.,Nizi, Emanuela,Carroll, Steven S.,Ludmerer, Steven W.,Burlein, Christine,Dimuzio, Jillian M.,Graham, Donald J.,McHale, Carolyn M.,Stahlhut, Mark W.,Olsen, David B.,Monteagudo, Edith,Cianetti, Simona,Giuliano, Claudio,Pucci, Vincenzo,Trainor, Nicole,Fandozzi, Christine M.,Rowley, Michael,Coleman, Paul J.,Vacca, Joseph P.,Summa, Vincenzo,Liverton, Nigel J.

supporting information; experimental part, p. 332 - 336 (2012/06/01)

A new class of HCV NS3/4a protease inhibitors containing a P2 to P4 macrocyclic constraint was designed using a molecular modeling-derived strategy. Building on the profile of previous clinical compounds and exploring the P2 and linker regions of the series allowed for optimization of broad genotype and mutant enzyme potency, cellular activity, and rat liver exposure following oral dosing. These studies led to the identification of clinical candidate 15 (MK-5172), which is active against genotype 1-3 NS3/4a and clinically relevant mutant enzymes and has good plasma exposure and excellent liver exposure in multiple species.

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