120656-71-5

Upstream product

• 3612-20-2 1-phenylmethyl-4-piperidone 
• 348-54-9 2-Fluoroaniline 

Downstream Products

• 120657-11-6 N-(2-Fluoro-phenyl)-N-{1-[2-(2-methyl-5-nitro-imidazol-1-yl)-ethyl]-4-phenyl-piperidin-4-yl}-propionamide 
• 120656-74-8 1-[2-(4-ethyl-4,5-dihydro-5-oxo-1H-tetrazol-1-yl)ethyl]-4-phenyl-4-[N-(2-fluorophenyl)propionamido]piperidine 
• 120656-96-4 N-(2-Fluoro-phenyl)-N-{1-[2-(2-oxo-benzooxazol-3-yl)-ethyl]-4-phenyl-piperidin-4-yl}-propionamide 
• 122823-19-2 N-{1-[2-(3,5-Dimethyl-pyrazol-1-yl)-ethyl]-4-phenyl-piperidin-4-yl}-N-(2-fluoro-phenyl)-propionamide 
• 120656-98-6 N-(2-Fluoro-phenyl)-N-{1-[2-(4-methyl-thiazol-5-yl)-ethyl]-4-phenyl-piperidin-4-yl}-propionamide 
• 122823-18-1 N-(2-Fluoro-phenyl)-N-{1-[2-(4-iodo-pyrazol-1-yl)-ethyl]-4-phenyl-piperidin-4-yl}-propionamide 
• 120656-91-9 N-(2-Fluoro-phenyl)-N-[4-phenyl-1-(2-thiophen-2-yl-ethyl)-piperidin-4-yl]-propionamide 
• 122823-10-3 N-(2-Fluoro-phenyl)-N-[4-phenyl-1-(2-pyrazol-1-yl-ethyl)-piperidin-4-yl]-propionamide 
• 122823-03-4 N-(2-Fluoro-phenyl)-N-[4-phenyl-1-(2-thiophen-3-yl-ethyl)-piperidin-4-yl]-propionamide 
• 120656-89-5 N-(2-Fluoro-phenyl)-N-(1-phenethyl-4-phenyl-piperidin-4-yl)-propionamide 
• 120656-73-7 1-benzyl-4-phenyl-4-piperidine 
• 122823-22-7 4-phenyl-4-piperidine 
• 6208-43-1 2-benzyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole 
• 120656-72-6 1-benzyl-4-phenyl-4-(2-fluoroanilino)piperidine 

Relevant academic research and scientific papers

Synthesis of substituted indoles and carbazoles from 2-fluorophenyl imines

The synthesis of a series of indole and carbazole derivatives from 2-fluorophenyl imines is reported. 2-Fluoroaniline-d4 (13) is prepared and used to investigate the mechanism of this indolization. 2-Fluorophenyl enaminone 17 gives the synthetically useful carbazole 20 via a similar indolization and in situ alkylation.

4-phenyl- and 4-heteroaryl-4-anilidopiperidines. A novel class of analgesic and anesthetic agents

The incorporation of the 4-phenylpiperidine pharmacophore found in morphine into 4-anilidopiperidines related to fentanyl led to a novel class of potent opioid analgesic and anesthetic agents with a favorable pharmacological profile. The synthesis analgesic activity, and anesthetic properties of a series of 4-phenyl-4-anilidopiperidines (13-29) are discussed. Isosteric replacement of the phenyl by various heteroaryl substituents extended the series to include 4-heteroaryl-4-anilidopiperidines (30-53). Within this group, 1-[2-(1H-pyrazol-1-yl)ethyl]4-4(4-methylthiazol-2-yl)-4-(N- phenylpropionamido)piperidine (48), exhibited high analgesic potency, short duration of action, rapid recovery of motor coordination following anesthetic doses, and greater cardiovascular and respiratory safety during anesthesia as compared with opioids fentanyl (1) and alfentanil (2) currently in clinical use. Such analgesics could be of great utility to clinicians in the expanding outpatient surgical arena and for patient-controlled analgesia and computer assisted continuous infusion pain control techniques.