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CAS

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1206687-12-8

[(4-{4-methyl-5-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazol-3-yl}bicyclo[2.2.2]oct-1-yl)methyl]amine is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 1206687-12-8 Structure

  • Basic information

    1. Product Name: [(4-{4-methyl-5-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazol-3-yl}bicyclo[2.2.2]oct-1-yl)methyl]amine
    2. Synonyms: [(4-{4-methyl-5-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazol-3-yl}bicyclo[2.2.2]oct-1-yl)methyl]amine
    3. CAS NO:1206687-12-8
    4. Molecular Formula:
    5. Molecular Weight: 364.414
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1206687-12-8.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: [(4-{4-methyl-5-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazol-3-yl}bicyclo[2.2.2]oct-1-yl)methyl]amine(CAS DataBase Reference)
    10. NIST Chemistry Reference: [(4-{4-methyl-5-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazol-3-yl}bicyclo[2.2.2]oct-1-yl)methyl]amine(1206687-12-8)
    11. EPA Substance Registry System: [(4-{4-methyl-5-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazol-3-yl}bicyclo[2.2.2]oct-1-yl)methyl]amine(1206687-12-8)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1206687-12-8(Hazardous Substances Data)

1206687-12-8 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1206687-12-8 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,0,6,6,8 and 7 respectively; the second part has 2 digits, 1 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1206687-12:
(9*1)+(8*2)+(7*0)+(6*6)+(5*6)+(4*8)+(3*7)+(2*1)+(1*2)=148
148 % 10 = 8
So 1206687-12-8 is a valid CAS Registry Number.

1206687-12-8Downstream Products

1206687-12-8Relevant articles and documents

Bicyclo[2.2.2]octyltriazole inhibitors of 11β-hydoxysteroid dehydrogenase type 1. Pharmacological agents for the treatment of metabolic syndrome

Maletic, Milana,Leeman, Aaron,Szymonifka, Michael,Mundt, Steven S.,Zokian, Hratch J.,Shah, Kashmira,Dragovic, Jasminka,Lyons, Kathy,Thieringer, Rolf,Vosatka, Anne H.,Balkovec, James,Waddell, Sherman T.

, p. 2568 - 2572 (2011)

Following the discovery of a metabolic 'soft-spot' on a bicyclo[2.2.2]octyltriazole lead, an extensive effort was undertaken to block the oxidative metabolism and improve PK of this potent HSD1 lead. In this communication, SAR survey focusing on various alkyl chain replacements will be detailed. This effort culminated in the discovery of a potent ethyl sulfone inhibitor with an improved PK profile across species and improved physical properties.

SEH AND 11β-HSD1 DUAL INHIBITORS

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Page/Page column 22; 23, (2010/04/03)

The invention is directed to bicycle[2.2.2]oct-1-yl compounds, pharmaceutical compositions containing them and their use in the treatment of a variety of conditions mediated by the sEH enzyme and/or the 11β-HSD1 enzyme.

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