1206694-75-8Relevant articles and documents
A new class of ezetimibe derivative and its preparation method (by machine translation)
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Paragraph 0036-0039; 0060-0062, (2019/03/08)
The present invention provides a new class of ezetimibe derivatives, characterized in that its structural formula as shown in formula I: The invention the ezetimibe derivatives improves the water-solubility of ezetimibe, more conducive to clinical use. (by machine translation)
Visible-Light Photocatalytic Synthesis of Amines from Imines via Transfer Hydrogenation Using Quantum Dots as Catalysts
Xi, Zi-Wei,Yang, Lei,Wang, Dan-Yan,Pu, Chao-Dan,Shen, Yong-Miao,Wu, Chuan-De,Peng, Xiao-Gang
, p. 11886 - 11895 (2018/09/25)
CdSe/CdS core/shell quantum dots (QDs) can be used as stable and highly active photoredox catalysts for efficient transfer hydrogenation of imines to amines with thiophenol as a hydrogen atom donor. This reaction proceeds via a proton-coupled electron transfer (PCET) from the QDs conduction band to the protonated imine followed by hydrogen atom transfer from the thiophenol to the α-aminoalkyl radical. This precious metal free transformation is easy to scale up and can be carried out by a one-pot protocol directly from aldehyde, amine, and thiophenol. Additional advantageous features of this protocol include a wide substrate scope, high yield of the amine products, extremely low catalyst loading (0.001 mol %), high turnover number (105), and the mild reaction conditions of using visible light or sun light at room temperature in neutral media.
METHOD FOR PRODUCING EZETIMIBE AND INTERMEDIATE THEREOF
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, (2017/03/08)
PROBLEM TO BE SOLVED: To provide a method for producing ezetimibe that is a cholesterol-lowering agent. SOLUTION: The present invention provides a method for producing ezetimibe (I) that generates intermediate (M1) and eliminates a protecting group. [R1 is a benzyl group and others, R2 is an ether protecting group such as a silyl ether protecting group]. SELECTED DRAWING: None COPYRIGHT: (C)2016,JPOandINPIT