1206707-47-2

Upstream product

• 109-97-7 pyrrole 
• 264881-99-4 methyl 2-(4-bromophenyl)-2-diazoacetate 
• 41841-16-1 (4-bromo-phenyl)-acetic acid methyl ester 

Relevant academic research and scientific papers

Blue LED Induced Manganese (I) Catalysed Direct C2?H Activation of Pyrroles with Aryl Diazoesters

Herein, we have reported a blue LED mediated manganese pentacarbonyl bromide catalysed incorporation of carbene moieties from aryl diazoesters onto 1H-pyrroles via their selective C2?H activation. A manganese metal-carbene has been identified as the active catalyst to facilitate the reaction. Eighteen mono substituted pyrrole derivatives were isolated in good to excellent yields (67→82%) and the disubstituted products were also formed in minor quantities (5 to 8%). HPLC based kinetics study enabled optimization of the reaction. Control experiments, FT-IR, NMR and GC-MS based characterization elucidated the putative reaction mechanism. (Figure presented.).

Ruthenium catalyzed directing group-free C2-selective carbenoid functionalization of indoles by α-aryldiazoesters

[Chemical equation presented] A directing group-free approach for C2-selective carbenoid functionalization of NH-indoles is presented. Using [RuCl2(p-cymene)]2 as catalyst and α-aryldiazoesters as carbenoid source, 2-alkylated indoles were obtained in up to 96% isolated yield. Similarly, a regioselective carbenoid functionalization of NH-pyrroles was also achieved.