120671-64-9Relevant academic research and scientific papers
2H-benzimidazoles (isobenzimidazoles). Part 10. Synthesis of polysubstituted o-phenylenediamines and their conversion into heterocycles, particularly 2-substituted benzimidazoles with known or potential anthelminthic activity
Hazelton,Iddon,Suschitzky,Woolley
, p. 10771 - 10794 (2007/10/02)
Polysubstituted o-phenylenediamines were synthesised in moderate to high yield by reductive cleavage of the corresponding 2H-benzimidazole-2-spirocyclohexane with sodium dithionite in aqueous ethanol and converted into methyl benzimidazole-2-carbamates and 2-methylthio- and 2-trifluoro-methylbenzimidazoles with known or potential anthelminthic activity. 5-(Pyrimidin-2-ylthio)-benzimidazole and 11-(pyridin-2-ylthio)dibenzo[a,c]phenazine were synthesized too. Attempts to oxidise 1,3-dihydro-2H-4,9-diazanaphth[2,3-d]imidazole, prepared by condensation of 2,3-diaminoquinoxaline with cyclohexanone, to an analogue of the title system failed.
2H-Benzimidazoles (Isobenzimidazoles); Part 4. Nucleophilic Substitution of 5,6-Dichloro-2H-benzimidazole-2-spirocyclohexane
Iddon, Brian,Robinson, Andrew G.,Suschitzky, H.
, p. 871 - 876 (2007/10/02)
Reaction conditions for mono- or di-substitution of the chloro substituents in 5,6-dichloro-2H-benzimidazole-2-spirocyclohexane (4) by various nucleophiles (RNH2, R2NH, RS(1-), RO(1-)) are reported.Conversion of 4-morpholino-5-phenylsulphonyl-2H-benzimida
