1206769-00-7Relevant articles and documents
Semipreparative HPLC enantioseparation, chiroptical properties, and absolute configuration of two novel cyclooxygenase-2 inhibitors
Cirilli, Roberto,Fiore, Stefano,La Torre, Francesco,Maccioni, Elias,Secci, Daniela,Sanna, Maria Luisa,Faggi, Cristina
, p. 56 - 62 (2010)
A direct semipreparative HPLC enantioseparation of two chiral thiazolidinone derivatives having cyclooxygenase-2 inhibition activity was performed on the Chiralpak IA chiral stationary phase. Semipreparative amounts of enantiopure forms were collected using acetonitrile-ethanol-trifluoroacetic acid mixtures as mobile phase. The absolute configuration of both compounds was unequivocally established by single-crystal X-ray diffraction method and correlated to the chiroptical properties of isolated enantiomers.