1206769-81-4

Basic information

• Product Name: N-[2-bromo-6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-pyrimidin-4-yl]-4-tert-butyl-benzenesulfonamide
• Synonyms: N-[2-bromo-6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-pyrimidin-4-yl]-4-tert-butyl-benzenesulfonamide
• CAS NO: 1206769-81-4
• Molecular Weight: 552.446
• Mol File: 1206769-81-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-[2-bromo-6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-pyrimidin-4-yl]-4-tert-butyl-benzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[2-bromo-6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-pyrimidin-4-yl]-4-tert-butyl-benzenesulfonamide(1206769-81-4)
• EPA Substance Registry System: N-[2-bromo-6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-pyrimidin-4-yl]-4-tert-butyl-benzenesulfonamide(1206769-81-4)

Safety Data

• Hazardous Substances Data: 1206769-81-4(Hazardous Substances Data)

Downstream Products

• 147536-97-8 bosentan 

Relevant articles and documents

PROCESS FOR THE PREPARATION OF BOSENTAN

The present invention provides a novel process for obtaining Bosentan, with few synthesis steps, by coupling the intermediate pyrimidine derivative of formula I with the sulfonamide derivative of formula II. The use of said process prevents the protection of the hydroxyl group of the sulfonamide II and thus is of considerable interest for obtaining Bosentan in a large industrial scale. The invention also refers to the intermediates of formula II and to a process for its production.