1206769-86-9Relevant articles and documents
PROCESS FOR THE PREPARATION OF BOSENTAN
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Page/Page column 12-13, (2010/04/03)
The present invention provides a novel process for obtaining Bosentan, with few synthesis steps, by coupling the intermediate pyrimidine derivative of formula I with the sulfonamide derivative of formula II. The use of said process prevents the protection of the hydroxyl group of the sulfonamide II and thus is of considerable interest for obtaining Bosentan in a large industrial scale. The invention also refers to the intermediates of formula II and to a process for its production.