1206788-45-5Relevant articles and documents
Biocatalytic Friedel-Crafts alkylation using non-natural cofactors
Stecher, Harald,Tengg, Martin,Ueberbacher, Bernhard J.,Remler, Peter,Schwab, Helmut,Griengl, Herfried,Gruber-Khadjawi, Mandona
, p. 9546 - 9548 (2009)
A novel biocatalytic protocol for C -C bond formation is described and is an equivalent to Friedel-Crafts alkylation. S-Adenosyl-L-methionine (SAM), the major Chemical Equation Presentation methyl donor for biological methylation catalyzed by methyltransferases (Mtases), can perform alkylations (see scheme). These enzymes can accept non-natural cofactors and transfer functionalities other than methyl onto aromatic substrates