1206845-55-7

Basic information

• Product Name: C₂₀H₂₆⁽²⁾H₄Cl₂N₂O₃Si
• CAS NO: 1206845-55-7
• Molecular Weight: 449.43
• Mol File: 1206845-55-7.mol

Chemical Properties

• CAS DataBase Reference: C₂₀H₂₆⁽²⁾H₄Cl₂N₂O₃Si(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₀H₂₆⁽²⁾H₄Cl₂N₂O₃Si(1206845-55-7)
• EPA Substance Registry System: C₂₀H₂₆⁽²⁾H₄Cl₂N₂O₃Si(1206845-55-7)

Safety Data

• Hazardous Substances Data: 1206845-55-7(Hazardous Substances Data)

Upstream product

• 78302-26-8 (+/-)-[4,4,5,5-(2)H4]-2-(1-[2,6-dichlorophenoxy]ethyl)-Δ2-imidazoline 
• 129919-88-6 (2S)-2-<(tert-Butyldimethylsilyl)oxy>lactic acid 

Relevant articles and documents

Rac- and R-(+)-[4,4′,5,5′-2H4]-2- (1′-[2″,6″-dichlorophenoxy]-ethyl)-Δ2- imidazoline (lofexidine)

The synthesis of the d4-forms of rac- and R-lofexidine was accomplished. Two methods are described; one method is a two-step synthesis of rac-d4-lofexidine from 2-chloropropionitrile, the second method is a three-step preparation of R-d4-lofexidine in absolute enantiomeric purity from S-methyl lactate. The commercial availability of R-methyl lactate makes this latter enantioselective synthesis applicable also to the synthesis of S-d4- lofexidine. These procedures also conserve the utilization of the relatively expensive [1,1′,2,2′-2H 4]ethylene diamine precursor. The availability of S- and R-d 4-lofexidines will enable pharmacokinetic studies to be carried out to determine if differential in vivo metabolism of the two enantiomers of lofexidine occurs. Copyright