1206897-85-9

Basic information

• Product Name: bis(2-phenylethyl)-6,9,10-trihydroxybenzo[k,l]xanthene-1,2-dicarboxylate
• Synonyms: bis(2-phenylethyl)-6,9,10-trihydroxybenzo[k,l]xanthene-1,2-dicarboxylate
• CAS NO: 1206897-85-9
• Molecular Weight: 562.576
• Mol File: 1206897-85-9.mol

Chemical Properties

• CAS DataBase Reference: bis(2-phenylethyl)-6,9,10-trihydroxybenzo[k,l]xanthene-1,2-dicarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: bis(2-phenylethyl)-6,9,10-trihydroxybenzo[k,l]xanthene-1,2-dicarboxylate(1206897-85-9)
• EPA Substance Registry System: bis(2-phenylethyl)-6,9,10-trihydroxybenzo[k,l]xanthene-1,2-dicarboxylate(1206897-85-9)

Safety Data

• Hazardous Substances Data: 1206897-85-9(Hazardous Substances Data)

Downstream Products

• 1206897-87-1 bis(2-phenylethyl) 6,9,10-tris(acetyloxy)benzo[kl]xanthene-1,2-dicarboxylate 
• 1273557-19-9 bis(2-phenylethyl) 6,9,10-trimethoxybenzo[kl]xanthene-1,2-dicarboxylate 

Relevant articles and documents

Bioinspired benzoxanthene lignans as a new class of antimycotic agents: synthesis and Candida spp. growth inhibition

In this work we synthetized the bioinspired benzoxanthene lignans (BXLs) 3, 14–22, and the phenazine derivative 23 as potential antimycotic agents. MICs and MFCs against Candida strains were determined. In a preliminary screening, compounds 3, 15, 20, 21,

Novel benzoxanthene lignans that favorably modulate lipid mediator biosynthesis: A promising pharmacological strategy for anti-inflammatory therapy

Lipid mediators (LM) encompass pro-inflammatory prostaglandins (PG) and leukotrienes (LT) but also specialized pro-resolving mediators (SPM) which display pivotal bioactivities in health and disease. Pharmacological intervention with inflammatory disorder

Synthesis, DNA/RNA-interaction and biological activity of benzo[k,l]xanthene lignans

Interactions of two newly synthesized and six previously reported benzoxanthene lignans (BXLs), analogues of rare natural products, with DNA/RNA, G-quadruplex and HSA were evaluated by a set of spectrophotometric methods. Presence/absence of methoxy and hydroxy groups on the benzoxanthene core and minor modifications at C-1/C-2 side pendants – presence/absence of phenyl ring and presence/absence of methoxy and hydroxy groups on phenyl ring – influenced the fluorescence changes and the binding strength to double-stranded (ds-) and G-quadruplex structures. In general, compounds without phenyl ring showed stronger fluorescence changes upon binding than phenyl-substituted BXLs. On the other hand, BXLs with an unsubstituted phenyl ring showed the best stabilization effects of G-quadruplex. Circular dichroism spectroscopy results suggest mixed binding mode, groove binding and partial intercalation, to ds-DNA/RNA and end-stacking to top or bottom G-tetrads as the main binding modes of BXLs to those targets. All compounds exhibited micromolar binding affinities toward HSA and an increased protein thermal stability. Moderate to strong antiradical scavenging activity was observed for all BXLs with hydroxy groups at C-6, C-9 and C-10 positions of the benzoxanthene core, except for derivative bearing methoxy groups at these positions. BXLs with unsubstituted or low-substituted phenyl ring and one derivative without phenyl ring showed strong growth inhibition of Gram-positive Staphylococcus aureus. All compounds showed moderate to strong tumor cell growth-inhibitory activity and cytotoxicity.

Biomimetic synthesis of natural and "unnatural" lignans by oxidative coupling of caffeic esters

The metal-mediated oxidative coupling of caffeic acid esters has been employed in the biomimetic synthesis of dimeric lignans and neolignans. Phenethyl and methyl caffeate esters were used as substrates and MnO 2, Mn(OAc)3 and Agsub