1206901-11-2Relevant academic research and scientific papers
Dual heterogeneous catalysis for a regioselective three-component synthesis of Bi-and Tri(hetero)arylpyridines
Allais, Christophe,Lieby-Muller, Frederic,Constantieux, Thierry,Rodriguez, Jean
, p. 2537 - 2544 (2012/10/30)
We have designed a new, user-friendly oxidative dual heterogeneous catalytic system capable of promoting polysubstituted pyridines as unique products from simple activated Michael acceptors, 1,3-dicarbonyls and ammonium acetate. This metal-free environmentally-respectful and totally regioselective domino reaction proved to be a great strategy to access bi- and triaryl-type pyridines as well as challenging bi- and triheteroaryl-type pyridines in a single operation. Copyright
Use of β,γ-unsaturated α-ketocarbonyls for a totally regioselective oxidative multicomponent synthesis of polyfunctionalized pyridines
Allais, Christophe,Constantieux, Thierry,Rodriguez, Jean
supporting information; experimental part, p. 12945 - 12948 (2010/05/19)
Versatile partners: α-Ketocarbonyls have been shown for the first time to be versatile partners in a Michael addition promoted oxidative domino threecomponent reaction under heterogeneous conditions. This multicomponent reaction sequence led to the development of a general synthesis of highly functionalized pyridines (see scheme), allowing selective and simultaneous incorporation of a substituent at the 4-position and a synthetically useful functionality at the strategic 2-position.
