1206978-15-5

Basic information

• Product Name: 2-chloro-4-(difluoroMethoxy)pyridine
• Synonyms: 2-chloro-4-(difluoroMethoxy)pyridine
• CAS NO: 1206978-15-5
• Molecular Formula: C6H4ClF2NO
• Molecular Weight: 179.5518664
• Mol File: 1206978-15-5.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 2-chloro-4-(difluoroMethoxy)pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-4-(difluoroMethoxy)pyridine(1206978-15-5)
• EPA Substance Registry System: 2-chloro-4-(difluoroMethoxy)pyridine(1206978-15-5)

Safety Data

• Hazardous Substances Data: 1206978-15-5(Hazardous Substances Data)

Usage

General Description

2-Chloro-4-(difluoromethoxy)pyridine is a chemical compound with the molecular formula C6H3ClF2NO. It is a halogenated pyridine derivative, containing a chlorine and two fluorine atoms, as well as a methoxy group. 2-Chloro-4-(difluoromethoxy)pyridine is commonly used as a building block for the synthesis of pharmaceuticals and agrochemicals. It has also been found to exhibit antitumor and anti-inflammatory activities in some studies. Additionally, 2-Chloro-4-(difluoromethoxy)pyridine is used as an intermediate in the manufacture of various synthetic organic compounds, making it a valuable reagent in the field of organic chemistry.

Upstream product

• 17368-12-6 2-chloropyridin-4-ol 
• 1885-46-7 trifluoromethanesulfonic acid difluoromethyl ether 

Relevant articles and documents

Tri- and difluoromethoxylated N-based heterocycles ? Synthesis and insecticidal activity of novel F3CO- and F2HCO-analogues of Imidacloprid and Thiacloprid

The preparation of F3CO- and F2HCO-analogues of Imidacloprid and Thiacloprid and the evaluation of their biological activity have been performed. For this purpose, a first synthetic approach allowed the preparation of a desired F3CO-containing key intermediate. To allow a facile access to the second F2HCO-containing key intermediate, the difluoromethylation of hydroxylated N-based heterocycles has been developed using difluoromethyl triflate (a liquid non-ODS reagent) under air in aqueous conditions and with very short reaction time. The broad diversity of compatible heterocycles includes a large series of substituted hydroxy-pyridines, but also ?pyrazoles, ?pyrazine, ?pyridazine, and ?quinolines. The couplings of both key intermediates with the required 4,5-dihydro-N-nitro-1H-imidazol-2-amine and [N(Z)]-N-2-thiazolidinylidene-cyanamide were successfully achieved using literature conditions. This work enables the preparation of valuable building blocks, which could lead to the discovery of new bioactive entities.