1207-00-7

Upstream product

• 90-04-0 2-methoxy-phenylamine 
• 28005-76-7 2-[2-hydroxyethyl-(2-methoxyphenyl)amino]ethanol 

Downstream Products

• 116283-15-9 1-(3-dodecyloxy-propyl)-4-(2-methoxy-phenyl)-piperazine 
• 64253-13-0 N,N-bis-(2-chloro-ethyl)-2-methoxy-4-(3-nitro-phenylazo)-aniline 
• 108842-71-3 1-(4-methoxy-butyl)-4-(2-methoxy-phenyl)-piperazine 
• 101428-23-3 1-(3-ethoxy-propyl)-4-(2-methoxy-phenyl)-piperazine 
• 103160-84-5 1-(5-methoxy-pentyl)-4-(2-methoxy-phenyl)-piperazine 
• 101780-43-2 1-(6-methoxy-hexyl)-4-(2-methoxy-phenyl)-piperazine 
• 102463-55-8 1-(3-hexyloxy-propyl)-4-(2-methoxy-phenyl)-piperazine 
• 110252-91-0 4-(2-methoxy-phenyl)-thiomorpholine 
• 100861-92-5 1-(2-methoxy-ethyl)-4-(2-methoxy-phenyl)-piperazine 
• 7008-00-6 1-(2-methoxy-phenyl)-4-(3-methoxy-propyl)-piperazine 
• 850884-18-3 1-(2-methoxyphenyl)-4-(3-fluorophenyl)-piperidine-4-carbonitrile 
• 850884-15-0 1-(2-methoxyphenyl)-4-(2-methoxyphenyl)-piperidine-4-carbonitrile 
• 867262-56-4 1-(2-methoxyphenyl)-4-phenylpiperidine-4-carbonitrile 
• 850884-17-2 1-(2-methoxyphenyl)-4-(4-methoxyphenyl)-piperidine-4-carbonitrile 

Relevant academic research and scientific papers

Synthesis and structure-analgesic activity relationships of a novel series of monospirocyclopiperazinium salts (MSPZ)

A series of monospirocyclopiperazinium salts were designed and synthesized to search for a peripherally-acting analgesic drug with low side effects. Extensive SAR studies revealed that a suitable NR2R3 was critical for the analgesic activity, which might be beneficial to expose the cationic nitrogen to bind to the receptor, and possibly interact with the receptor via π-π interaction. Introduction of substituting group on the N4-phenyl ring could improve the activity, and the best position was the 4-position. Compound 14n showed more potent analgesic activity (63%, 20 μM/kg, sc) and holds promise for development as a mechanically new analgesic drug.

NOVEL PIPERIDINE DERIVATIVE

The invention provides a compound of the following formula (1): wherein m, n, and p are independently an integer of 0 - 4, provided 3 ≤ m + n ≤ 8; X is nitrogen atom or a group of the formula: C-R15; Y is a substituted or unsubstituted aromatic group, etc.; R15, R1, R2, R3, R4 , R5, R6 and R7 are hydrogen atom, a substituted or unsubstituted alkyl group, etc.; and Z is hydrogen atom, cyano group, etc., or a prodrug thereof, or a pharmaceutically acceptable salt thereof, which exhibits an action for enhancing LDL receptor expression, and is useful as a medicament for treating hyperlipidemia, atherosclerosis, etc.