1207-25-6

Upstream product

• 1217-99-8 5-methyl-1-(4-nitrophenyl)-1H-1,2,3-triazole-4-carboxylic acid 
• 1516-60-5 4-nitrophenyl azide 
• 4202-14-6 dimethyl (2-oxopropyl)phosphonate 

Downstream Products

• 84292-45-5 1-(4-Aminophenyl)-5-methyl-1,2,3-triazole 
• 890641-79-9 5-(5-methyl-1H-1,2,3-triazol-1-yl)-3-phenyl-2,1-benzisoxazole 
• 890641-73-3 3-(4-chlorophenyl)-5-(5-methyl-1H-1,2,3-triazol-1-yl)-2,1-benzisoxazole 
• 84292-49-9 [4-(5-Methyl-[1,2,3]triazol-1-yl)-phenoxy]-acetic acid ethyl ester 

Relevant academic research and scientific papers

Regioselective N/C-heterocyclization of allenylindium bromide across aryl azides: One-pot synthesis of 5-methyl-1,2,3-triazoles

An unprecedented, one-pot regioselective synthesis of 1,5-disubstituted 1,2,3-triazoles through N/C-heterocyclization of allenylindium bromide across aryl azides is described. The synthesis is carried out under mild conditions in aqueous medium and procee

Synthesis of 2,1-benzisoxazoles by nucleophilic substitution of hydrogen in nitroarenes activated by the azole ring

Reaction of 1-nitro-4-(1,2,3-triazolyl/tetrazolyl)benzenes with arylacetonitriles in an alcoholic medium in the presence of excess alkali gives novel 2,1-benzisoxazoles. These findings indicate a high reactivity of nitroarenes activated by the azole ring due to their electron-deficient character. Moreover, it was found that annulation of the isoxazole ring occurred regioselectively in disubstituted nitroarenes. In the case of 1-(4-nitrophenyl)-1H-tetrazole, the tetrazole ring cleaved faster than the sH-adduct was formed. Georg Thieme Verlag Stuttgart.