1207163-85-6

Basic information

• Product Name: C₁₃H₁₂ClN₅O₂
• Synonyms: C₁₃H₁₂ClN₅O₂
• CAS NO: 1207163-85-6
• Molecular Weight: 305.724
• Mol File: 1207163-85-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₃H₁₂ClN₅O₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₃H₁₂ClN₅O₂(1207163-85-6)
• EPA Substance Registry System: C₁₃H₁₂ClN₅O₂(1207163-85-6)

Safety Data

• Hazardous Substances Data: 1207163-85-6(Hazardous Substances Data)

Upstream product

• 5096-73-1 6-chloro-pyridazine-3-carboxylic acid 
• 320608-52-4 C₈H₁₁N₃O 

Relevant articles and documents

Novel spiropiperidine-based stearoyl-CoA desaturase-1 inhibitors: Identification of 1′-{6-[5-(pyridin-3-ylmethyl)-1,3,4-oxadiazol-2-yl]pyridazin-3-yl}-5-(trifluoromethyl)-3,4-dihydrospiro[chromene-2,4′-piperidine]

Cyclization of the benzoylpiperidine in lead compound 2 generated a series of novel and highly potent spiropiperidine-based stearoyl-CoA desaturase (SCD)-1 inhibitors. Among them, 1′-{6-[5-(pyridin-3-ylmethyl)-1,3,4-oxadiazol-2-yl]pyridazin-3-yl}-5-(trifluoromethyl)-3,4-dihydrospiro[chromene-2,4′-piperidine] (19) demonstrated the most powerful inhibitory activity against SCD-1, not only in vitro but also in vivo (C57BL/6 J mice). With regard to the pharmacological evaluation, 19 showed powerful reduction of the desaturation index in the plasma of C57BL/6 J mice on a non-fat diet after a 7-day oral administration (q.d.) without causing notable abnormalities in the eyes or skin up to the highest dose (3 mg/kg) in our preliminary analysis.