1207166-41-3

Upstream product

• 1207166-37-7 14,20-bis(tert-butyl-dimethyl-silanyloxy)-8,10-dihydroxy-7,13,15,17,19,21-hexamethyl-22-(1-methyl-penta-2,4-dienyl)-oxacyclodocosa-3,5,11,16-tetraen-2-one 
• 149198-47-0 tert-butyl (3R,4S)-2-oxo-4-phenyl-3-(triethylsilyloxy)azetidine-1-carboxylate 
• 1207166-39-9 3-tert-butoxycarbonylamino-2-hydroxy-3-phenyl-propionic acid 10,14,20-trihydroxy-7,13,15,17,19,21-hexamethyl-22-(1-methyl-penta-2,4-dienyl)-2-oxo-oxacyclodocosa-3,5,11,16-tetraen-8-yl ester 
• 939383-45-6 C₂₀H₂₄F₆IO₆P 
• 1266549-20-5 C₅₇H₁₀₈O₆Si₄ 
• 1082395-62-7 C₄₈H₈₄O₆Si₂ 
• 1082395-54-7 C₅₀H₈₅IO₆Si₂ 
• 1082395-59-2 C₄₂H₇₇IO₅Si₂ 
• 1082395-60-5 C₄₂H₇₉IO₅Si₂ 
• 1082395-55-8 C₄₅H₈₃IO₅Si₂ 
• 1082395-61-6 C₄₈H₈₆O₇Si₂ 
• 373645-86-4 (5Z,13Z)-(2R,3R,4S,8S,9R,10R,11S,12S)-3,9-bis(tertbutyldimethylsilanyloxy)-11-hydroxy-2,4,6,8,10,12-hexamethylhexadeca-5,13,15-trienal 

Downstream Products

• 1207166-39-9 3-tert-butoxycarbonylamino-2-hydroxy-3-phenyl-propionic acid 10,14,20-trihydroxy-7,13,15,17,19,21-hexamethyl-22-(1-methyl-penta-2,4-dienyl)-2-oxo-oxacyclodocosa-3,5,11,16-tetraen-8-yl ester 

Relevant academic research and scientific papers

Total synthesis and biological evaluation of a series of macrocyclic hybrids and analogues of the antimitotic natural products dictyostatin, discodermolide, and taxol

The design, synthesis, and biological evaluation of a series of hybrids and analogues of the microtubule-stabilizing anticancer agents dictyostatin, discodermolide, and taxol is described. A 22-membered macrolide scaffold was prepared by adapting earlier

Total synthesis of a library of designed hybrids of the microtubule-stabilising anticancer agents taxol, discodermolide and dictyostatin

A hybrid library of the marine natural products dictyostatin and discodermolide, incorporating the taxol or taxotere side chains, were synthesised; preliminary biological evaluation in the PANC-1 cancer cell line revealed significant antiproliferative activity, demonstrating that a macrolide scaffold is an effective surrogate for the baccatin core of taxol.