1207166-75-3

Upstream product

• 1489-97-0 ethyl 1,4-dioxaspiro[4.5]decane-8-carboxylate 
• 17159-79-4 ethyl 4-oxocyclohexane-1-carboxylate 
• 72653-14-6 1,5-di-tert-butyl 3-ethyl 3-acetylpentane-1,3,5-tricarboxylate 
• 141-97-9 ethyl acetoacetate 
• 1135619-58-7 1,5-di-tert-butyl 3-ethyl 3-acetylpentane-1,3,5-tricarboxylate 
• 72653-21-5 ethyl 1-acetyl-4-oxocyclohexane-1-carboxylate 
• 100-46-9 benzylamine 

Downstream Products

• 135908-45-1 ethyl 4-aminobicyclo[2.2.2]octane-1-carboxylate 
• 1207166-77-5 ethyl 4-(benzylamino)-2-hydroxybicyclo[2.2.2]octane-1-carboxylate 
• 1207166-78-6 ethyl 4-(benzylamino)-2-((methylsulfonyl)oxy)bicyclo[2.2.2]octane-1-carboxylate 
• 1207166-79-7 ethyl 4-(benzylamino)bicyclo[2.2.2]oct-2-ene-1-carboxylate 
• 1544658-10-7 4-((6-(trans-4-tert-butylcyclohexyloxy)naphthalen-2-yl)methylamino)-2-hydroxybicylo[2.2.2]octane-1-carboxylic acid 
• 1544662-62-5 ethyl 4-((6-(trans-4-tert-butylcyclohexyloxy)naphthalen-2-yl)methylamino)-2-hydroxybicyclo[2.2.2]octane-1-carboxylate 
• 1544658-13-0 4-((6-(trans-4-tert-butylcyclohexyloxy)naphthalen-2-yl)methylamino)-1-(hydroxymethyl)bicyclo[2.2.2]octan-2-ol 

Relevant academic research and scientific papers

PRODRUG MODULATORS OF THE INTEGRATED STRESS PATHWAY

Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases, disorders and conditions.

MODULATORS OF THE INTEGRATED STRESS PATHWAY

Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.

MODULATORS OF THE INTEGRATED STRESS PATHWAY

Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.

MODULATORS OF THE INTEGRATED STRESS PATHWAY

Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.

MODULATORS OF THE INTEGRATED STRESS PATHWAY

Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.

PYRAZOLE AMIDE DERIVATIVE

The present invention relates to a novel compound having a function of inhibiting RORγ activity. The present invention also relates to pharmaceutical composition comprising the compound, a use of the compound in treating or preventing autoimmune diseases, inflammatory diseases, metabolic diseases, or cancer diseases.

COMPOUNDS THAT ARE S1P MODULATING AGENTS AND/OR ATX MODULATING AGENTS

Compounds of formula (I) can modulate the activity of one or more S1P receptors and/or the activity of autotaxin (ATX).

PROCESS FOR PRODUCTION OF BICYCLOY2.2.2¨OCTYLAMINE DERIVATIVE

The present invention herein provides a process for production or a bicyclo[2.2.2]octylamine derivative which may be used as an intermediate for preparation of medical and pharmaceutical products. The process is quite efficient and can produce the derivative in a large-scale while using mild reaction conditions. The process for producing a bicyclo[2.2.2]octylamine derivative comprises the steps of subjecting, to ring-formation, a compound represented by the following general formula (1): [wherein R1 represents an alkyl group having 1 to 6 carbon atoms, which may have a substituent; an arylmethyl group which may have a substituent; or an arylethyl group which may have a substituent], and a compound represented by the following general formula (2): ????????R2-NH2?????(2) [wherein R2 represents an alkyl group having 1 to 6 carbon atoms, which may have a substituent; an aralkyl group which may have a substituent; a hydroxyl group; an alkyloxy group having 1 to 6 carbon atoms, which may have a substituent; or an aralkyloxy group which may have a substituent], and then reducing the resulting product.